Necrotizing Enterocolitis and the Microbiome: Current Status and Future Directions.
J Infect Dis
; 223(12 Suppl 2): S257-S263, 2021 06 16.
Article
en En
| MEDLINE
| ID: mdl-33330904
ABSTRACT
Decades of research have failed to define the pathophysiology of necrotizing enterocolitis (NEC), a devastating pediatric gastrointestinal disorder of preterm infants. However, evidence suggests that host-microbiota interactions, in which microbial dysbiosis is followed by loss of barrier integrity, inflammation, and necrosis, are central to NEC development. Thus, greater knowledge of the preterm infant microbiome could accelerate attempts to diagnose, treat, and prevent NEC. In this article, we summarize clinical characteristics of and risk factors for NEC, the structure of the pre-event NEC microbiome, how this community interfaces with host immunology, and microbiome-based approaches that might prevent or lessen the severity of NEC in this very vulnerable population.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Enterocolitis Necrotizante
/
Microbioma Gastrointestinal
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Humans
/
Newborn
Idioma:
En
Revista:
J Infect Dis
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos