ERK-dependent suicide gene therapy for selective targeting of RTK/RAS-driven cancers.

Day, Evan K; Campbell, Anne; Pandolf, Ashley; Rogerson, Troy; Zhong, Qing; Xiao, Aizhen; Purow, Benjamin; Lazzara, Matthew J

Day, Evan K; Campbell, Anne; Pandolf, Ashley; Rogerson, Troy; Zhong, Qing; Xiao, Aizhen; Purow, Benjamin; Lazzara, Matthew J.

Afiliación

Day EK; Department of Chemical Engineering, University of Virginia, Charlottesville, VA 22904-4741, USA; Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
Campbell A; Department of Chemical Engineering, University of Virginia, Charlottesville, VA 22904-4741, USA.
Pandolf A; Department of Chemical Engineering, University of Virginia, Charlottesville, VA 22904-4741, USA.
Rogerson T; Department of Chemical Engineering, University of Virginia, Charlottesville, VA 22904-4741, USA.
Zhong Q; Department of Neurology, University of Virginia, Charlottesville, VA 22908, USA.
Xiao A; Department of Neurology, University of Virginia, Charlottesville, VA 22908, USA.
Purow B; Department of Neurology, University of Virginia, Charlottesville, VA 22908, USA.
Lazzara MJ; Department of Chemical Engineering, University of Virginia, Charlottesville, VA 22904-4741, USA; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: mlazzara@virginia.edu.

Mol Ther ; 29(4): 1585-1601, 2021 04 07.

Article en En | MEDLINE | ID: mdl-33333291

Asunto(s)

Citosina Desaminasa/genética; Genes Transgénicos Suicidas/genética; Terapia Genética; Neoplasias/terapia; Timidina Quinasa/genética; Animales; Citosina Desaminasa/farmacología; Quinasas MAP Reguladas por Señal Extracelular/genética; Vectores Genéticos/genética; Xenoinjertos; Humanos; Ratones; Neoplasias/genética; Neoplasias/patología; Simplexvirus/enzimología; Timidina Quinasa/farmacología; Células Tumorales Cultivadas; Proteínas ras/genética

Palabras clave

5-fluorocytosine; ERK; FRA1; extracellular signal-regulated kinase; ganciclovir; glioblastoma; herpes simplex virus thymidine kinase; yeast cytosine deaminase

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Timidina Quinasa / Terapia Genética / Citosina Desaminasa / Genes Transgénicos Suicidas / Neoplasias Límite: Animals / Humans Idioma: En Revista: Mol Ther Asunto de la revista: BIOLOGIA MOLECULAR / TERAPEUTICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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