Decreasing HepG2 Cytotoxicity by Lowering the Lipophilicity of Benzo[d]oxazolephosphinate Ester Utrophin Modulators.

Chatzopoulou, Maria; Emer, Enrico; Lecci, Cristina; Rowley, Jessica A; Casagrande, Anne-Sophie; Moir, Lee; Squire, Sarah E; Davies, Stephen G; Harriman, Shawn; Wynne, Graham M; Wilson, Francis X; Davies, Kay E; Russell, Angela J

Chatzopoulou, Maria; Emer, Enrico; Lecci, Cristina; Rowley, Jessica A; Casagrande, Anne-Sophie; Moir, Lee; Squire, Sarah E; Davies, Stephen G; Harriman, Shawn; Wynne, Graham M; Wilson, Francis X; Davies, Kay E; Russell, Angela J.

Afiliación

Chatzopoulou M; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, U.K.
Emer E; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, U.K.
Lecci C; Evoetec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Milton, Abingdon OX14 4RZ, U.K.
Rowley JA; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, U.K.
Casagrande AS; Evotec (France) SAS, 195 Route d'Espagne, 31100 Toulouse, France.
Moir L; MDUK Oxford Neuromuscular Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, U.K.
Squire SE; MDUK Oxford Neuromuscular Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, U.K.
Davies SG; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, U.K.
Harriman S; Summit Therapeutics plc, 136a Eastern Avenue, Milton Park, Abingdon, Oxfordshire OX14 4SB, U.K.
Wynne GM; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, U.K.
Wilson FX; Summit Therapeutics plc, 136a Eastern Avenue, Milton Park, Abingdon, Oxfordshire OX14 4SB, U.K.
Davies KE; MDUK Oxford Neuromuscular Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, U.K.
Russell AJ; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, U.K.

ACS Med Chem Lett ; 11(12): 2421-2427, 2020 Dec 10.

Article en En | MEDLINE | ID: mdl-33335663

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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: ACS Med Chem Lett Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido