A validated UHPLC-MS/MS method for determination of TQ-B3203 in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor.

Yang, Fen; Zhou, Jun; Bo, Yunhai; Yin, Han; Liu, Xiao Hong; Li, Jian

Yang, Fen; Zhou, Jun; Bo, Yunhai; Yin, Han; Liu, Xiao Hong; Li, Jian.

Afiliación

Yang F; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), National drug clinical trial center, Peking University Cancer Hospital & Institute, Beijing, P. R. China.
Zhou J; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital & Institute, Beijing, P. R. China.
Bo Y; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), National drug clinical trial center, Peking University Cancer Hospital & Institute, Beijing, P. R. China.
Yin H; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), National drug clinical trial center, Peking University Cancer Hospital & Institute, Beijing, P. R. China.
Liu XH; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), National drug clinical trial center, Peking University Cancer Hospital & Institute, Beijing, P. R. China.
Li J; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital & Institute, Beijing, P. R. China.

J Sep Sci ; 44(5): 945-953, 2021 Mar.

Article en En | MEDLINE | ID: mdl-33340437

Asunto(s)

Neoplasias/metabolismo; Pueblo Asiatico; Cromatografía Líquida de Alta Presión; Relación Dosis-Respuesta a Droga; Humanos; Estructura Molecular; Espectrometría de Masas en Tándem

Palabras clave

TQ-B3203; mass spectrometry; pharmacokinetics; solid tumor

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Límite: Humans Idioma: En Revista: J Sep Sci Año: 2021 Tipo del documento: Article