Mechanistic Oral Absorption Modeling of Halofantrine: Exploring the Role of Intestinal Lymphatic Transport.

Dolton, Michael J; Chiang, Po-Chang; Chen, Yuan

Dolton, Michael J; Chiang, Po-Chang; Chen, Yuan.

Afiliación

Dolton MJ; Clinical Pharmacology, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: dolton.michael@gene.com.
Chiang PC; Small Molecule Pharmaceutical Sciences, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Chen Y; Drug Metabolism and Pharmacokinetics, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA.

J Pharm Sci ; 110(3): 1427-1430, 2021 03.

Article en En | MEDLINE | ID: mdl-33359312

Asunto(s)

Fenantrenos; Administración Oral; Absorción Intestinal; Intestinos; Linfa; Modelos Biológicos; Periodo Posprandial

Palabras clave

Absorption; Food effect(s); Lipid(s); Lymphatic transport; PBPK

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fenantrenos Idioma: En Revista: J Pharm Sci Año: 2021 Tipo del documento: Article