Pathogenic gene prediction based on network embedding.
Brief Bioinform
; 22(4)2021 07 20.
Article
en En
| MEDLINE
| ID: mdl-33367541
In disease research, the study of gene-disease correlation has always been an important topic. With the emergence of large-scale connected data sets in biology, we use known correlations between the entities, which may be from different sets, to build a biological heterogeneous network and propose a new network embedded representation algorithm to calculate the correlation between disease and genes, using the correlation score to predict pathogenic genes. Then, we conduct several experiments to compare our method to other state-of-the-art methods. The results reveal that our method achieves better performance than the traditional methods.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Algoritmos
/
Biología Computacional
/
Redes Reguladoras de Genes
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Brief Bioinform
Asunto de la revista:
BIOLOGIA
/
INFORMATICA MEDICA
Año:
2021
Tipo del documento:
Article
País de afiliación:
China