Real-world experience of ocrelizumab in multiple sclerosis in a Spanish population.
Ann Clin Transl Neurol
; 8(2): 385-394, 2021 02.
Article
en En
| MEDLINE
| ID: mdl-33369288
ABSTRACT
OBJECTIVE:
Pivotal trial have shown that patients with multiple sclerosis (MS) receiving ocrelizumab had better outcomes. However, data on ocrelizumab in clinical practice are limited. The aim of this study was to evaluate the preliminary safety profile and effectiveness of ocrelizumab treatment for multiple sclerosis (MS) in a real-world clinical setting.METHODS:
We conducted a retrospective study including consecutive patients from nine public hospitals in south-eastern Spain who received ocrelizumab after it was approved.RESULTS:
A total of 228 MS patients were included (144 with relapsing-remitting MS [RRMS], 25 secondary progressive MS [SPMS], and 59 primary progressive MS [PPMS]). Median follow-up period was 12 months (range, 1-32). No evidence of disease activity (NEDA) status at year 1 was achieved in 91.2% of the relapsing MS (RMS) population, while disability progression was detected in 37.5% of the PPMS patients (median follow-up period, 19 months). The most common adverse events reported were infusion-related reactions and infections, with the most common infections being urinary tract infections followed by upper respiratory infections and COVID-19.INTERPRETATION:
The preliminary results in our real-world setting show that ocrelizumab presented excellent results in suppressing disease activity with a favorable and consistent safety profile.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Esclerosis Múltiple Crónica Progresiva
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Esclerosis Múltiple Recurrente-Remitente
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Anticuerpos Monoclonales Humanizados
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Factores Inmunológicos
Tipo de estudio:
Observational_studies
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Ann Clin Transl Neurol
Año:
2021
Tipo del documento:
Article
País de afiliación:
España