Coordination of Multiple Cellular Processes by NR5A1/Nr5a1.
Endocrinol Metab (Seoul)
; 35(4): 756-764, 2020 12.
Article
en En
| MEDLINE
| ID: mdl-33397036
ABSTRACT
The agenesis of the gonads and adrenal gland in revealed by knockout mouse studies strongly suggested a crucial role for Nr5a1 (SF-1 or Ad4BP) in organ development. In relation to these striking phenotypes, NR5A1/Nr5a1 has the potential to reprogram cells to steroidogenic cells, endow pluripotency, and regulate cell proliferation. However, due to limited knowledge regarding NR5A1 target genes, the mechanism by which NR5A1/Nr5a1 regulates these fundamental processes has remained unknown. Recently, newlyestablished technologies have enabled the identification of NR5A1 target genes related to multiple metabolic processes, as well as the aforementioned biological processes. Considering that active cellular processes are expected to be accompanied by active metabolism, NR5A1 may act as a key factor for processes such as cell differentiation, proliferation, and survival by coordinating these processes with cellular metabolism. A complete and definite picture of the cellular processes coordinated by NR5A1/Nr5a1 could be depicted by accumulating evidence of the potential target genes through whole genome studies.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Glándulas Suprarrenales
/
Factor Esteroidogénico 1
/
Glucólisis
/
Gónadas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Endocrinol Metab (Seoul)
Año:
2020
Tipo del documento:
Article
País de afiliación:
Japón