Bacteriophage-resistant Acinetobacter baumannii are resensitized to antimicrobials.
Nat Microbiol
; 6(2): 157-161, 2021 02.
Article
en En
| MEDLINE
| ID: mdl-33432151
ABSTRACT
We characterized two bacteriophages, ΦFG02 and ΦCO01, against clinical isolates of Acinetobacter baumannii and established that the bacterial capsule is the receptor for these phages. Phage-resistant mutants harboured loss-of-function mutations in genes responsible for capsule biosynthesis, resulting in capsule loss and disruption of phage adsorption. The phage-resistant strains were resensitized to human complement, beta-lactam antibiotics and alternative phages and exhibited diminished fitness in vivo. Using a mouse model of A. baumannii infection, we showed that phage therapy was effective.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Bacteriófagos
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Infecciones por Acinetobacter
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Acinetobacter baumannii
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Terapia de Fagos
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Antibacterianos
Límite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Nat Microbiol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Australia