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Bacteriophage-resistant Acinetobacter baumannii are resensitized to antimicrobials.
Gordillo Altamirano, Fernando; Forsyth, John H; Patwa, Ruzeen; Kostoulias, Xenia; Trim, Michael; Subedi, Dinesh; Archer, Stuart K; Morris, Faye C; Oliveira, Cody; Kielty, Luisa; Korneev, Denis; O'Bryan, Moira K; Lithgow, Trevor J; Peleg, Anton Y; Barr, Jeremy J.
Afiliación
  • Gordillo Altamirano F; School of Biological Sciences, Monash University, Clayton, Victoria, Australia. fernando.gordilloaltamirano@monash.edu.
  • Forsyth JH; School of Biological Sciences, Monash University, Clayton, Victoria, Australia.
  • Patwa R; School of Biological Sciences, Monash University, Clayton, Victoria, Australia.
  • Kostoulias X; Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria, Australia.
  • Trim M; School of Biological Sciences, Monash University, Clayton, Victoria, Australia.
  • Subedi D; School of Biological Sciences, Monash University, Clayton, Victoria, Australia.
  • Archer SK; Monash Bioinformatics Platform, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia.
  • Morris FC; Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria, Australia.
  • Oliveira C; School of Biological Sciences, Monash University, Clayton, Victoria, Australia.
  • Kielty L; School of Biological Sciences, Monash University, Clayton, Victoria, Australia.
  • Korneev D; School of Biological Sciences, Monash University, Clayton, Victoria, Australia.
  • O'Bryan MK; School of Biological Sciences, Monash University, Clayton, Victoria, Australia.
  • Lithgow TJ; Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria, Australia.
  • Peleg AY; Centre to Impact AMR, Monash University, Clayton, Victoria, Australia.
  • Barr JJ; Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria, Australia.
Nat Microbiol ; 6(2): 157-161, 2021 02.
Article en En | MEDLINE | ID: mdl-33432151
ABSTRACT
We characterized two bacteriophages, ΦFG02 and ΦCO01, against clinical isolates of Acinetobacter baumannii and established that the bacterial capsule is the receptor for these phages. Phage-resistant mutants harboured loss-of-function mutations in genes responsible for capsule biosynthesis, resulting in capsule loss and disruption of phage adsorption. The phage-resistant strains were resensitized to human complement, beta-lactam antibiotics and alternative phages and exhibited diminished fitness in vivo. Using a mouse model of A. baumannii infection, we showed that phage therapy was effective.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Bacteriófagos / Infecciones por Acinetobacter / Acinetobacter baumannii / Terapia de Fagos / Antibacterianos Límite: Animals / Female / Humans Idioma: En Revista: Nat Microbiol Año: 2021 Tipo del documento: Article País de afiliación: Australia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Bacteriófagos / Infecciones por Acinetobacter / Acinetobacter baumannii / Terapia de Fagos / Antibacterianos Límite: Animals / Female / Humans Idioma: En Revista: Nat Microbiol Año: 2021 Tipo del documento: Article País de afiliación: Australia