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Breastfeeding promotes early neonatal regulatory T-cell expansion and immune tolerance of non-inherited maternal antigens.
Wood, Hannah; Acharjee, Animesh; Pearce, Hayden; Quraishi, Mohammed Nabil; Powell, Richard; Rossiter, Amanda; Beggs, Andrew; Ewer, Andrew; Moss, Paul; Toldi, Gergely.
Afiliación
  • Wood H; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
  • Acharjee A; Department of Neonatology, Birmingham Women's and Children's NHS FT, Birmingham, UK.
  • Pearce H; Centre for Computational Biology, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
  • Quraishi MN; Institute of Translational Medicine, University Hospitals Birmingham NHS FT, Birmingham, UK.
  • Powell R; NIHR Surgical Reconstruction and Microbiology Research Centre, University Hospitals Birmingham NHS FT, Birmingham, UK.
  • Rossiter A; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
  • Beggs A; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
  • Ewer A; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
  • Moss P; Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK.
  • Toldi G; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Allergy ; 76(8): 2447-2460, 2021 08.
Article en En | MEDLINE | ID: mdl-33432577
ABSTRACT

BACKGROUND:

Breastfeeding is associated with long-term health benefits, such as a lower incidence of childhood infections, asthma, obesity and autoimmune disorders. However, little is known regarding how the maternal and neonatal immune systems interact after parturition when the neonate receives nutrition from maternal breast milk.

METHODS:

We undertook a comparative analysis of immune repertoire and function at birth and 3 weeks of age in a cohort of 38 term neonates born by caesarean section grouped according to feeding method (breast milk versus formula). We used flow cytometry to study the immune phenotype in neonatal and maternal blood samples and mixed lymphocyte reactions to establish the proliferation response of neonatal versus maternal lymphocytes and vice versa. The microbiome of neonatal stool samples was also investigated using 16S rRNA sequencing.

RESULTS:

We show that the proportion of regulatory T cells (Tregs) increases in this period and is nearly twofold higher in exclusively breastfed neonates compared with those who received formula milk only. Moreover, breastfed neonates show a specific and Treg-dependent reduction in proliferative T-cell responses to non-inherited maternal antigens (NIMA), associated with a reduction in inflammatory cytokine production. We also observed the enrichment of short chain fatty acid producing taxa (Veillonella and Gemella) in stool samples of exclusively breastfed neonates.

CONCLUSIONS:

These data indicate that exposure of the neonate to maternal cells through breastfeeding acts to drive the maturation of Tregs and 'tolerizes' the neonate towards NIMA.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Lactancia Materna / Linfocitos T Reguladores Límite: Female / Humans / Newborn / Pregnancy Idioma: En Revista: Allergy Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Lactancia Materna / Linfocitos T Reguladores Límite: Female / Humans / Newborn / Pregnancy Idioma: En Revista: Allergy Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido