Runx1 is a central regulator of osteogenesis for bone homeostasis by orchestrating BMP and WNT signaling pathways.

Tang, Chen-Yi; Wu, Mengrui; Zhao, Dongfeng; Edwards, Diep; McVicar, Abigail; Luo, Yuan; Zhu, Guochun; Wang, Yongjun; Zhou, Hou-De; Chen, Wei; Li, Yi-Ping

Tang, Chen-Yi; Wu, Mengrui; Zhao, Dongfeng; Edwards, Diep; McVicar, Abigail; Luo, Yuan; Zhu, Guochun; Wang, Yongjun; Zhou, Hou-De; Chen, Wei; Li, Yi-Ping.

Afiliación

Tang CY; Department of Pathology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, United States of America.
Wu M; Department of Metabolism & Endocrinology, Hunan provincial Key Laboratory of Metabolic Bone Diseases, National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhao D; Department of Pathology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, United States of America.
Edwards D; Institute of Genetics, Life Science College, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
McVicar A; Department of Pathology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, United States of America.
Luo Y; Shanghai University of Traditional Chinese Medicine, Pudong, Shanghai, China P.R.
Zhu G; Department of Pathology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, United States of America.
Wang Y; Department of Pathology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, United States of America.
Zhou HD; Department of Pathology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, United States of America.
Chen W; Department of Pathology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, United States of America.
Li YP; Shanghai University of Traditional Chinese Medicine, Pudong, Shanghai, China P.R.

PLoS Genet ; 17(1): e1009233, 2021 01.

Article en En | MEDLINE | ID: mdl-33476325

Asunto(s)

Proteína Morfogenética Ósea 7/genética; Receptores de Proteínas Morfogenéticas Óseas de Tipo 1/genética; Subunidad alfa 2 del Factor de Unión al Sitio Principal/genética; Osteogénesis/genética; Osteoporosis/genética; Factor de Transcripción Activador 4/genética; Adipocitos/metabolismo; Adipogénesis/genética; Animales; Colágeno Tipo I/genética; Cadena alfa 1 del Colágeno Tipo I; Subunidad alfa 1 del Factor de Unión al Sitio Principal/genética; Proteínas de Unión al ADN/genética; Regulación del Desarrollo de la Expresión Génica/genética; Homeostasis/genética; Humanos; Células Madre Mesenquimatosas; Ratones; Ratones Noqueados; Osteoblastos/metabolismo; Osteoporosis/patología; Regiones Promotoras Genéticas/genética; RNA-Seq; Proteínas Represoras/genética; Proteína Smad1/genética; Proteína 1 Relacionada con Twist/genética; Vía de Señalización Wnt/genética

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Osteogénesis / Osteoporosis / Receptores de Proteínas Morfogenéticas Óseas de Tipo 1 / Subunidad alfa 2 del Factor de Unión al Sitio Principal / Proteína Morfogenética Ósea 7 Límite: Animals / Humans Idioma: En Revista: PLoS Genet Asunto de la revista: GENETICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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