Rational Design of New Dihydrobenzooxophosphole-Based Lewis Base Organocatalysts.
Synlett
; 31(6): 587-591, 2020 Apr.
Article
en En
| MEDLINE
| ID: mdl-33542591
ABSTRACT
A series of new dihydrobenzooxophosphole-based Lewis Base organocatalysts were designed and synthesized. They are demonstrated effective in trichlorosilane-mediated stereoselective conjugate reductions of C=C bonds. DFT calculations reveal that the strong hydrogen bond between the amide linker and the chloride on silicon in the transition state contributes to the high reactivity of the catalyst 3a.
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MEDLINE
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Synlett
Año:
2020
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Article
País de afiliación:
Estados Unidos