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A novel partially open state of SHP2 points to a "multiple gear" regulation mechanism.
Tao, Youqi; Xie, Jingfei; Zhong, Qinglu; Wang, Yongyao; Zhang, Shengnan; Luo, Feng; Wen, Fengcai; Xie, Jingjing; Zhao, Jiawei; Sun, Xiaoou; Long, Houfang; Ma, Junfeng; Zhang, Qian; Long, Jiangang; Fang, Xianyang; Lu, Ying; Li, Dan; Li, Ming; Zhu, Jidong; Sun, Bo; Li, Guohui; Diao, Jiajie; Liu, Cong.
Afiliación
  • Tao Y; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
  • Xie J; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China; University of the Chinese Academy of Sciences, Beijing, China.
  • Zhong Q; University of the Chinese Academy of Sciences, Beijing, China; Laboratory of Molecular Modeling and Design, State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
  • Wang Y; Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Oh
  • Zhang S; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China; University of the Chinese Academy of Sciences, Beijing, China.
  • Luo F; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China; University of the Chinese Academy of Sciences, Beijing, China.
  • Wen F; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
  • Xie J; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China; University of the Chinese Academy of Sciences, Beijing, China.
  • Zhao J; Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China.
  • Sun X; Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China.
  • Long H; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China; University of the Chinese Academy of Sciences, Beijing, China.
  • Ma J; Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China.
  • Zhang Q; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
  • Long J; Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China.
  • Fang X; Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China.
  • Lu Y; University of the Chinese Academy of Sciences, Beijing, China; Beijing National Laboratory for Condensed Matter Physics and CAS Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China.
  • Li D; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
  • Li M; University of the Chinese Academy of Sciences, Beijing, China; Beijing National Laboratory for Condensed Matter Physics and CAS Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China.
  • Zhu J; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China; University of the Chinese Academy of Sciences, Beijing, China.
  • Sun B; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
  • Li G; University of the Chinese Academy of Sciences, Beijing, China; Laboratory of Molecular Modeling and Design, State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China. Electronic address: ghli@dicp.ac.cn.
  • Diao J; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. Electronic address: jiajie.diao@uc.edu.
  • Liu C; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China; University of the Chinese Academy of Sciences, Beijing, China. Electronic address: liulab@sioc.ac.cn.
J Biol Chem ; 296: 100538, 2021.
Article en En | MEDLINE | ID: mdl-33722610
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Piperidinas / Pirimidinas / Calgranulina A / Proteína Tirosina Fosfatasa no Receptora Tipo 11 / Proteínas Sustrato del Receptor de Insulina Límite: Humans Idioma: En Revista: J Biol Chem Año: 2021 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Piperidinas / Pirimidinas / Calgranulina A / Proteína Tirosina Fosfatasa no Receptora Tipo 11 / Proteínas Sustrato del Receptor de Insulina Límite: Humans Idioma: En Revista: J Biol Chem Año: 2021 Tipo del documento: Article País de afiliación: China