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Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect.
Ibrahim, Tarek S; Hawwas, Mohamed M; Malebari, Azizah M; Taher, Ehab S; Omar, Abdelsattar M; Neamatallah, Thikryat; Abdel-Samii, Zakaria K; Safo, Martin K; Elshaier, Yaseen A M M.
Afiliación
  • Ibrahim TS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Hawwas MM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
  • Malebari AM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
  • Taher ES; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Omar AM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
  • Neamatallah T; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Abdel-Samii ZK; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
  • Safo MK; Department of Pharmacology and toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Elshaier YAMM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
J Enzyme Inhib Med Chem ; 36(1): 802-818, 2021 Dec.
Article en En | MEDLINE | ID: mdl-33730937
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Quinolinas / Estilbenos / Tubulina (Proteína) / Apoptosis / Moduladores de Tubulina / Descubrimiento de Drogas / Antineoplásicos Tipo de estudio: Guideline Límite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Arabia Saudita
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Quinolinas / Estilbenos / Tubulina (Proteína) / Apoptosis / Moduladores de Tubulina / Descubrimiento de Drogas / Antineoplásicos Tipo de estudio: Guideline Límite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Arabia Saudita