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Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP/PS1 murine model of Alzheimer's disease via inhibition of ACSL4-dependent ferroptosis.
Zhu, Zhi-Yun; Liu, Yan-Dong; Gong, Yan; Jin, Wei; Topchiy, Elena; Turdi, Subat; Gao, Yue-Feng; Culver, Bruce; Wang, Shu-Yi; Ge, Wei; Zha, Wen-Liang; Ren, Jun; Pei, Zhao-Hui; Qin, Xing.
Afiliación
  • Zhu ZY; Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, 330006, China.
  • Liu YD; The Second Department of Cardiology, The Third Hospital of Nanchang, Nanchang, 330009, China.
  • Gong Y; The Second Department of Cardiology, The Third Hospital of Nanchang, Nanchang, 330009, China.
  • Jin W; The Second Department of Cardiology, The Third Hospital of Nanchang, Nanchang, 330009, China.
  • Topchiy E; University of Wyoming College of Health Sciences, Laramie, WY, USA.
  • Turdi S; University of Wyoming College of Health Sciences, Laramie, WY, USA.
  • Gao YF; University of Wyoming College of Health Sciences, Laramie, WY, USA.
  • Culver B; State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, 100083, China.
  • Wang SY; University of Wyoming College of Health Sciences, Laramie, WY, USA.
  • Ge W; University of Wyoming College of Health Sciences, Laramie, WY, USA.
  • Zha WL; Department of General Practice, Xijing Hospital, the Air Force Military Medical University, Xi'an, 710032, China.
  • Ren J; Department of Surgery, Clinic Medical College, Hubei University of Science and Technology, Xianning, 437100, China.
  • Pei ZH; National Demonstration Center for Experimental General Medicine Education, Hubei University of Science and Technology, Xianning, 437100, China.
  • Qin X; University of Wyoming College of Health Sciences, Laramie, WY, USA. jren_aldh2@outlook.com.
Acta Pharmacol Sin ; 43(1): 39-49, 2022 Jan.
Article en En | MEDLINE | ID: mdl-33767380
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Precursor de Proteína beta-Amiloide / Coenzima A Ligasas / Modelos Animales de Enfermedad / Presenilina-1 / Enfermedad de Alzheimer / Aldehído Deshidrogenasa Mitocondrial Límite: Animals Idioma: En Revista: Acta Pharmacol Sin Asunto de la revista: FARMACOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Precursor de Proteína beta-Amiloide / Coenzima A Ligasas / Modelos Animales de Enfermedad / Presenilina-1 / Enfermedad de Alzheimer / Aldehído Deshidrogenasa Mitocondrial Límite: Animals Idioma: En Revista: Acta Pharmacol Sin Asunto de la revista: FARMACOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China