Effect of genipin-1-ß-d-gentiobioside on diabetic nephropathy in mice by activating AMP-activated protein kinase/silencing information regulator-related enzyme 1/ nuclear factor-&#954;B pathway.

Li, Fengtao; Song, Lijun; Chen, Jing; Chen, Yu; Li, Yongjun; Huang, Meizi; Zhao, Wenchang

Effect of genipin-1-ß-d-gentiobioside on diabetic nephropathy in mice by activating AMP-activated protein kinase/silencing information regulator-related enzyme 1/ nuclear factor-κB pathway.

Li, Fengtao; Song, Lijun; Chen, Jing; Chen, Yu; Li, Yongjun; Huang, Meizi; Zhao, Wenchang.

Afiliación

Li F; Jiangsu Agri-animal Husbandry Vocational College, Taizhou, Jiangsu, PR China.
Song L; Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University, Zhanjiang, Guangdong, PR China.
Chen J; School of Pharmacy, Guangdong Medical University, Dongguan, Guangdong, PR China.
Chen Y; Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, PR China.
Li Y; Jiangsu Agri-animal Husbandry Vocational College, Taizhou, Jiangsu, PR China.
Huang M; Jiangsu Agri-animal Husbandry Vocational College, Taizhou, Jiangsu, PR China.
Zhao W; Jiangsu Agri-animal Husbandry Vocational College, Taizhou, Jiangsu, PR China.

J Pharm Pharmacol ; 73(9): 1201-1211, 2021 Aug 12.

Article en En | MEDLINE | ID: mdl-33792721

Asunto(s)

Proteínas Quinasas Activadas por AMP/metabolismo; Nefropatías Diabéticas/metabolismo; Gardenia/química; Iridoides/farmacología; Riñón/efectos de los fármacos; FN-kappa B/metabolismo; Sirtuina 1/metabolismo; Animales; Diabetes Mellitus Experimental/complicaciones; Diabetes Mellitus Experimental/tratamiento farmacológico; Diabetes Mellitus Experimental/metabolismo; Nefropatías Diabéticas/tratamiento farmacológico; Inflamación; Iridoides/uso terapéutico; Riñón/metabolismo; Riñón/patología; Masculino; Ratones Endogámicos C57BL; Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo; Estrés Oxidativo; Fitoterapia; Extractos Vegetales/farmacología; Extractos Vegetales/uso terapéutico; Podocitos/efectos de los fármacos

Palabras clave

APMK/SIRT1/NF-κB pathway; diabetic nephropathy; genipin-1-ß-D-gentiobioside; inflammatory response; oxidative stress

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: FN-kappa B / Gardenia / Iridoides / Nefropatías Diabéticas / Proteínas Quinasas Activadas por AMP / Sirtuina 1 / Riñón Límite: Animals Idioma: En Revista: J Pharm Pharmacol Año: 2021 Tipo del documento: Article

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