Strategies for drug target identification in Mycobacterium leprae.
Drug Discov Today
; 26(7): 1569-1573, 2021 07.
Article
en En
| MEDLINE
| ID: mdl-33798649
ABSTRACT
Hansen's disease (HD), or leprosy, continues to be endemic in many parts of the world. Although multidrug therapy (MDT) is successful in curing a large number of patients, some of them abandon it because it is a long-term treatment. Therefore, identification of new drug targets in Mycobacterium leprae is considered of high importance. Here, we introduce an overview of in silico and in vitro studies that might be of help in this endeavor. The essentiality of M. leprae proteins is reviewed with discussion of flux balance analysis, gene expression, and knockout articles. Finally, druggability techniques are proposed for the validation of new M. leprae protein targets (see Fig. 1).
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Leprostáticos
/
Lepra
/
Mycobacterium leprae
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Drug Discov Today
Asunto de la revista:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Año:
2021
Tipo del documento:
Article