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A Placebo-Controlled, Pseudo-Randomized, Crossover Trial of Botanical Agents for Gulf War Illness: Curcumin (Curcuma longa), Boswellia (Boswellia serrata), and French Maritime Pine Bark (Pinus pinaster).
Donovan, Emily K; Kekes-Szabo, Sophia; Lin, Joanne C; Massey, Rebecca L; Cobb, James D; Hodgin, Kathleen S; Ness, Timothy J; Hangee-Bauer, Carl; Younger, Jarred W.
Afiliación
  • Donovan EK; Department of Psychology, Virginia Commonwealth University, White House, 806 West Franklin Street, Richmond, VA 23284, USA.
  • Kekes-Szabo S; Department of Psychology, Vanderbilt University, PMB 407817, 2301 Vanderbilt Place, Nashville, TN 37240, USA.
  • Lin JC; School of Pharmacy, University of Auckland, 85 Park Road, Grafton, Auckland 1023, New Zealand.
  • Massey RL; UAB School of Medicine, University of Alabama at Birmingham, 1670 University Blvd, Birmingham, AL 35223, USA.
  • Cobb JD; Department of Psychology, University of Alabama at Birmingham, CH 233, 1300 University Blvd, Birmingham, AL 35233, USA.
  • Hodgin KS; Department of Psychology, University of Alabama at Birmingham, CH 233, 1300 University Blvd, Birmingham, AL 35233, USA.
  • Ness TJ; Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, BMR2-208, 901 19th St. S, Birmingham, AL 35205, USA.
  • Hangee-Bauer C; San Francisco Natural Medicine, 1615 20th Street, San Francisco, CA 94107, USA.
  • Younger JW; Department of Psychology, University of Alabama at Birmingham, CH 233, 1300 University Blvd, Birmingham, AL 35233, USA.
Article en En | MEDLINE | ID: mdl-33802272
ABSTRACT
This report is part of a larger study designed to rapidly and efficiently screen potential treatments for Gulf War Illness (GWI) by testing nine different botanicals. In this placebo-controlled, pseudo-randomized, crossover clinical trial of 20 men with GWI, we tested three botanical agents with putative peripheral and central anti-inflammatory actions curcumin (Curcuma longa), boswellia (Boswellia serrata), and French maritime pine bark extract (Pinus pinaster). Participants completed 30 +/- 3 days of baseline symptom reports, followed by 30 +/- 3 days of placebo, 30 +/- 3 days of lower-dose botanical, and 30 +/- 3 days of higher-dose botanical. Participants then repeated the process with a new botanical until completing up to three botanical cycles. Data were analyzed using linear mixed models. Curcumin reduced GWI symptom severity significantly more than placebo at both the lower (p < 0.0001) and higher (p = 0.0003) dosages. Boswellia was not more effective than placebo at reducing GWI symptoms at either the lower (p = 0.726) or higher (p = 0.869) dosages. Maritime pine was not more effective than placebo at the lower dosage (p = 0.954) but was more effective than placebo at the higher dosage (p = 0.006). This study provides preliminary evidence that curcumin and maritime pine may help alleviate symptoms of GWI. As a screening study, a final determination of the efficacy of these compounds for all individuals with GWI cannot be made, and further studies will need to be conducted to determine strength and durability of effects, as well as optimal dosage. These results suggest that GWI may, at least in part, involve systemic inflammatory processes. This trial was registered on ClinicalTrials.gov (NCT02909686) on 13 September 2016.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Síndrome del Golfo Pérsico / Curcumina / Boswellia / Pinus Tipo de estudio: Clinical_trials Límite: Humans / Male Idioma: En Revista: Int J Environ Res Public Health Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Síndrome del Golfo Pérsico / Curcumina / Boswellia / Pinus Tipo de estudio: Clinical_trials Límite: Humans / Male Idioma: En Revista: Int J Environ Res Public Health Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos