PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma.

Wang, Jianfeng; Wang, Chen; Xu, Pan; Li, Xiao; Lu, Yongning; Jin, Di; Yin, Xiaomao; Jiang, Hao; Huang, Jing; Xiong, Huan; Ye, Fei; Jin, Jia; Chen, Yu; Xie, Yiqian; Chen, Zhifeng; Ding, Hong; Zhang, Hao; Liu, Rongfeng; Jiang, Hualiang; Chen, Kaixian; Yao, Zhiyi; Luo, Cheng; Huang, Yiran; Zhang, Yuanyuan; Zhang, Jin

Wang, Jianfeng; Wang, Chen; Xu, Pan; Li, Xiao; Lu, Yongning; Jin, Di; Yin, Xiaomao; Jiang, Hao; Huang, Jing; Xiong, Huan; Ye, Fei; Jin, Jia; Chen, Yu; Xie, Yiqian; Chen, Zhifeng; Ding, Hong; Zhang, Hao; Liu, Rongfeng; Jiang, Hualiang; Chen, Kaixian; Yao, Zhiyi; Luo, Cheng; Huang, Yiran; Zhang, Yuanyuan; Zhang, Jin.

Afiliación

Wang J; Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.
Wang C; Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Xu P; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China.
Li X; Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Lu Y; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China.
Jin D; Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Yin X; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China.
Jiang H; Zhongshan hospital Fudan University, 180 Fenglin road, Shanghai 200032, China.
Huang J; Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.
Xiong H; Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.
Ye F; Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Jin J; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China.
Chen Y; Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Xie Y; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China.
Chen Z; Department of Chemistry, College of Sciences, Shanghai University, 99 Shangda Road, Shanghai 200444, China.
Ding H; Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Zhang H; College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310023, China.
Liu R; College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310023, China.
Jiang H; Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Chen K; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China.
Yao Z; PerkinElmer Management (Shanghai) Co. Ltd, 1670 Zhangheng Road, Zhangjiang High-Tech Park, Shanghai 201203, China.
Luo C; Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Huang Y; Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Zhang Y; Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Zhang J; In vitro Biology, Shanghai ChemPartner Life Science Co., Ltd., #5 Building, 998 Halei Road, Shanghai 201203, China.

Theranostics ; 11(11): 5387-5403, 2021.

Article en En | MEDLINE | ID: mdl-33859753

Asunto(s)

Carcinoma de Células Renales/genética; Neoplasias Renales/genética; Proteína-Arginina N-Metiltransferasas/genética; Proteínas Represoras/genética; Animales; Biomarcadores de Tumor/genética; Carcinogénesis/genética; Carcinoma de Células Renales/tratamiento farmacológico; Puntos de Control del Ciclo Celular/efectos de los fármacos; Puntos de Control del Ciclo Celular/genética; Línea Celular; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Proliferación Celular/genética; Epigénesis Genética/genética; Femenino; Fase G1/efectos de los fármacos; Fase G1/genética; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Regulación Neoplásica de la Expresión Génica/genética; Células HEK293; Humanos; Neoplasias Renales/tratamiento farmacológico; Lipocalina 2/genética; Ratones; Ratones Endogámicos BALB C; Ratones Desnudos; Ratones SCID; Neutrófilos/efectos de los fármacos; Pronóstico; Transducción de Señal/efectos de los fármacos; Transducción de Señal/genética; Sunitinib/farmacología; Regulación hacia Arriba/efectos de los fármacos; Regulación hacia Arriba/genética

Palabras clave

clear cell renal cell carcinoma; lipocalin2 (LCN2); protein arginine methyltransferase 1; sunitinib; therapeutic

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteína-Arginina N-Metiltransferasas / Proteínas Represoras / Carcinoma de Células Renales / Neoplasias Renales Tipo de estudio: Prognostic_studies Idioma: En Revista: Theranostics Año: 2021 Tipo del documento: Article País de afiliación: China

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