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Immune cells fold and damage fungal hyphae.
Bain, Judith M; Alonso, M Fernanda; Childers, Delma S; Walls, Catriona A; Mackenzie, Kevin; Pradhan, Arnab; Lewis, Leanne E; Louw, Johanna; Avelar, Gabriela M; Larcombe, Daniel E; Netea, Mihai G; Gow, Neil A R; Brown, Gordon D; Erwig, Lars P; Brown, Alistair J P.
Afiliación
  • Bain JM; Aberdeen Fungal Group, Institute of Medical Sciences, Foresterhill, AB25 2ZD Aberdeen, United Kingdom.
  • Alonso MF; Aberdeen Fungal Group, Institute of Medical Sciences, Foresterhill, AB25 2ZD Aberdeen, United Kingdom.
  • Childers DS; Aberdeen Fungal Group, Institute of Medical Sciences, Foresterhill, AB25 2ZD Aberdeen, United Kingdom.
  • Walls CA; Aberdeen Fungal Group, Institute of Medical Sciences, Foresterhill, AB25 2ZD Aberdeen, United Kingdom.
  • Mackenzie K; Microscopy and Histology Facility, Institute of Medical Sciences, Foresterhill, AB25 2ZD Aberdeen, United Kingdom.
  • Pradhan A; Aberdeen Fungal Group, Institute of Medical Sciences, Foresterhill, AB25 2ZD Aberdeen, United Kingdom.
  • Lewis LE; Medical Research Council Centre for Medical Mycology, University of Exeter, EX4 4QD Exeter, United Kingdom.
  • Louw J; Aberdeen Fungal Group, Institute of Medical Sciences, Foresterhill, AB25 2ZD Aberdeen, United Kingdom.
  • Avelar GM; Aberdeen Fungal Group, Institute of Medical Sciences, Foresterhill, AB25 2ZD Aberdeen, United Kingdom.
  • Larcombe DE; Aberdeen Fungal Group, Institute of Medical Sciences, Foresterhill, AB25 2ZD Aberdeen, United Kingdom.
  • Netea MG; Aberdeen Fungal Group, Institute of Medical Sciences, Foresterhill, AB25 2ZD Aberdeen, United Kingdom.
  • Gow NAR; Medical Research Council Centre for Medical Mycology, University of Exeter, EX4 4QD Exeter, United Kingdom.
  • Brown GD; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500HB Nijmegen, The Netherlands.
  • Erwig LP; Department for Immunology and Metabolism, Life and Medical Sciences Institute, University of Bonn, 53115 Bonn, Germany.
  • Brown AJP; Aberdeen Fungal Group, Institute of Medical Sciences, Foresterhill, AB25 2ZD Aberdeen, United Kingdom.
Proc Natl Acad Sci U S A ; 118(15)2021 04 13.
Article en En | MEDLINE | ID: mdl-33876755
ABSTRACT
Innate immunity provides essential protection against life-threatening fungal infections. However, the outcomes of individual skirmishes between immune cells and fungal pathogens are not a foregone conclusion because some pathogens have evolved mechanisms to evade phagocytic recognition, engulfment, and killing. For example, Candida albicans can escape phagocytosis by activating cellular morphogenesis to form lengthy hyphae that are challenging to engulf. Through live imaging of C. albicans-macrophage interactions, we discovered that macrophages can counteract this by folding fungal hyphae. The folding of fungal hyphae is promoted by Dectin-1, ß2-integrin, VASP, actin-myosin polymerization, and cell motility. Folding facilitates the complete engulfment of long hyphae in some cases and it inhibits hyphal growth, presumably tipping the balance toward successful fungal clearance.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fagocitosis / Candida albicans / Hifa / Macrófagos Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fagocitosis / Candida albicans / Hifa / Macrófagos Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido