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Radiation-related genomic profile of papillary thyroid carcinoma after the Chernobyl accident.
Morton, Lindsay M; Karyadi, Danielle M; Stewart, Chip; Bogdanova, Tetiana I; Dawson, Eric T; Steinberg, Mia K; Dai, Jieqiong; Hartley, Stephen W; Schonfeld, Sara J; Sampson, Joshua N; Maruvka, Yosef E; Kapoor, Vidushi; Ramsden, Dale A; Carvajal-Garcia, Juan; Perou, Charles M; Parker, Joel S; Krznaric, Marko; Yeager, Meredith; Boland, Joseph F; Hutchinson, Amy; Hicks, Belynda D; Dagnall, Casey L; Gastier-Foster, Julie M; Bowen, Jay; Lee, Olivia; Machiela, Mitchell J; Cahoon, Elizabeth K; Brenner, Alina V; Mabuchi, Kiyohiko; Drozdovitch, Vladimir; Masiuk, Sergii; Chepurny, Mykola; Zurnadzhy, Liudmyla Yu; Hatch, Maureen; Berrington de Gonzalez, Amy; Thomas, Gerry A; Tronko, Mykola D; Getz, Gad; Chanock, Stephen J.
Afiliación
  • Morton LM; Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA. chanocks@mail.nih.gov mortonli@mail.nih.gov.
  • Karyadi DM; Laboratory of Genetic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Stewart C; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Bogdanova TI; Laboratory of Morphology of the Endocrine System, V. P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine, Kyiv 04114, Ukraine.
  • Dawson ET; Laboratory of Genetic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Steinberg MK; Nvidia Corporation, Santa Clara, CA 95051, USA.
  • Dai J; Cancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Bethesda, MD 20892, USA.
  • Hartley SW; Cancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Bethesda, MD 20892, USA.
  • Schonfeld SJ; Laboratory of Genetic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Sampson JN; Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Maruvka YE; Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Kapoor V; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Ramsden DA; Cancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Bethesda, MD 20892, USA.
  • Carvajal-Garcia J; Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Perou CM; Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Parker JS; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Krznaric M; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Yeager M; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Boland JF; Department of Surgery and Cancer, Imperial College London, Charing Cross Hospital, London W6 8RF, UK.
  • Hutchinson A; Cancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Bethesda, MD 20892, USA.
  • Hicks BD; Cancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Bethesda, MD 20892, USA.
  • Dagnall CL; Cancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Bethesda, MD 20892, USA.
  • Gastier-Foster JM; Cancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Bethesda, MD 20892, USA.
  • Bowen J; Cancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Bethesda, MD 20892, USA.
  • Lee O; Nationwide Children's Hospital, Biospecimen Core Resource, Columbus, OH 43205, USA.
  • Machiela MJ; Departments of Pathology and Pediatrics, Ohio State University College of Medicine, Columbus, OH 43210, USA.
  • Cahoon EK; Nationwide Children's Hospital, Biospecimen Core Resource, Columbus, OH 43205, USA.
  • Brenner AV; Laboratory of Genetic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Mabuchi K; Integrative Tumor Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Drozdovitch V; Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Masiuk S; Radiation Effects Research Foundation, Hiroshima 732-0815, Japan.
  • Chepurny M; Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Zurnadzhy LY; Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Hatch M; Radiological Protection Laboratory, Institute of Radiation Hygiene and Epidemiology, National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Kyiv 04050, Ukraine.
  • Berrington de Gonzalez A; Radiological Protection Laboratory, Institute of Radiation Hygiene and Epidemiology, National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Kyiv 04050, Ukraine.
  • Thomas GA; Laboratory of Morphology of the Endocrine System, V. P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine, Kyiv 04114, Ukraine.
  • Tronko MD; Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Getz G; Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Chanock SJ; Department of Surgery and Cancer, Imperial College London, Charing Cross Hospital, London W6 8RF, UK.
Science ; 372(6543)2021 05 14.
Article en En | MEDLINE | ID: mdl-33888599
ABSTRACT
The 1986 Chernobyl nuclear power plant accident increased papillary thyroid carcinoma (PTC) incidence in surrounding regions, particularly for radioactive iodine (131I)-exposed children. We analyzed genomic, transcriptomic, and epigenomic characteristics of 440 PTCs from Ukraine (from 359 individuals with estimated childhood 131I exposure and 81 unexposed children born after 1986). PTCs displayed radiation dose-dependent enrichment of fusion drivers, nearly all in the mitogen-activated protein kinase pathway, and increases in small deletions and simple/balanced structural variants that were clonal and bore hallmarks of nonhomologous end-joining repair. Radiation-related genomic alterations were more pronounced for individuals who were younger at exposure. Transcriptomic and epigenomic features were strongly associated with driver events but not radiation dose. Our results point to DNA double-strand breaks as early carcinogenic events that subsequently enable PTC growth after environmental radiation exposure.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias de la Tiroides / Accidente Nuclear de Chernóbil / Cáncer Papilar Tiroideo / Mutación / Neoplasias Inducidas por Radiación Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Science Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias de la Tiroides / Accidente Nuclear de Chernóbil / Cáncer Papilar Tiroideo / Mutación / Neoplasias Inducidas por Radiación Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Science Año: 2021 Tipo del documento: Article