Gestational sleep apnea perturbations induce metabolic disorders by divergent epigenomic regulation.
Epigenomics
; 13(10): 751-765, 2021 05.
Article
en En
| MEDLINE
| ID: mdl-33929266
ABSTRACT
Aim:
Late-gestational sleep fragmentation (LG-SF) and intermittent hypoxia (LG-IH), two hallmarks of obstructive sleep apnea, lead to metabolic dysfunction in the offspring. We investigated specific biological processes that are epigenetically regulated by LG-SF and LG-IH. Materials &methods:
We analyzed DNA methylation profiles in offspring visceral white adipose tissues by MeDIP-chip followed by pathway analysis.Results:
We detected 1187 differentially methylated loci (p < 0.01) between LG-SF and LG-IH. Epigenetically regulated genes in LG-SF offspring were associated with lipid and glucose metabolism, whereas those in LG-IH were related to inflammatory signaling and cell proliferation.Conclusion:
While LG-SF and LG-IH will result in equivalent phenotypic alterations in offspring, each paradigm appears to operate through epigenetic regulation of different biological processes.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Efectos Tardíos de la Exposición Prenatal
/
Síndromes de la Apnea del Sueño
/
Hipoxia
/
Enfermedades Metabólicas
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Epigenomics
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos