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Viral hepatitis in haemophilia: historical perspective and current management.
Isfordink, Cas J; van Erpecum, Karel J; van der Valk, Marc; Mauser-Bunschoten, Evelien P; Makris, Michael.
Afiliación
  • Isfordink CJ; Van Creveldkliniek, Department of Benign Haematology, University Medical Center Utrecht, Utrecht, the Netherlands.
  • van Erpecum KJ; Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, the Netherlands.
  • van der Valk M; Department of Internal Medicine, Division of Infectious Diseases, Amsterdam Institute for Infection and Immunity, University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
  • Mauser-Bunschoten EP; Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, the Netherlands.
  • Makris M; Department of Internal Medicine, Division of Infectious Diseases, Amsterdam Institute for Infection and Immunity, University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
Br J Haematol ; 195(2): 174-185, 2021 10.
Article en En | MEDLINE | ID: mdl-33955555
ABSTRACT
The introduction of clotting factor concentrates has substantially improved the lives of people with clotting factor deficiencies. Unfortunately, the transmission of blood-borne viral infections through these plasma-derived products led to a huge epidemic of human immunodeficiency virus and viral hepatitis in people with haemophilia (PWH). In a significant proportion of PWH exposed to these viruses, the ensuing decades-long chronic infection resulted in excess morbidity and mortality. Fortunately, developments in the safety of blood products, as well as vaccination and highly effective antiviral treatments have improved the prospects of PWH. The present article reviews the background of the viral hepatitis epidemic in PWH, the natural history of hepatitis B and C infections and their long-term management.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Infecciones por VIH / Infecciones de Transmisión Sanguínea / Hemofilia A / Hepatitis Viral Humana Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Adolescent / Adult / Aged / Aged80 / Humans / Middle aged Idioma: En Revista: Br J Haematol Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Infecciones por VIH / Infecciones de Transmisión Sanguínea / Hemofilia A / Hepatitis Viral Humana Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Adolescent / Adult / Aged / Aged80 / Humans / Middle aged Idioma: En Revista: Br J Haematol Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos