Podocytic Infolding Glomerulopathy in a Patient with Phospholipase A2 Receptor-Positive Membranous Nephropathy and Review of the Literature.
Nephron
; 145(5): 496-502, 2021.
Article
en En
| MEDLINE
| ID: mdl-33965947
ABSTRACT
Podocytic infolding glomerulopathy (PIG) is a rare diagnosis based on characteristic histopathologic findings on renal biopsy and was proposed as a new entity about a decade ago. It is a type of podocytic injury, characterized by invagination of the podocyte cell membrane (cytoplasmic projections from podocytes) into the glomerular basement membrane. The presence of microspheres and/or microtubules on electron microscopy is the characteristic finding. PIG is most often associated with autoimmune conditions like systemic lupus erythematosus. We report pathologic findings typical of PIG in a patient with phospholipase A2 receptor antibody-positive membranous nephropathy. She was treated with rituximab and responded well with decrease in proteinuria to the sub-nephrotic range.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Glomerulonefritis Membranosa
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Podocitos
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Receptores de Fosfolipasa A2
Límite:
Female
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Humans
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Middle aged
Idioma:
En
Revista:
Nephron
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos