A cell type-specific cortico-subcortical brain circuit for investigatory and novelty-seeking behavior.
Science
; 372(6543)2021 May 14.
Article
en En
| MEDLINE
| ID: mdl-33986154
ABSTRACT
Exploring the physical and social environment is essential for understanding the surrounding world. We do not know how novelty-seeking motivation initiates the complex sequence of actions that make up investigatory behavior. We found in mice that inhibitory neurons in the medial zona incerta (ZIm), a subthalamic brain region, are essential for the decision to investigate an object or a conspecific. These neurons receive excitatory input from the prelimbic cortex to signal the initiation of exploration. This signal is modulated in the ZIm by the level of investigatory motivation. Increased activity in the ZIm instigates deep investigative action by inhibiting the periaqueductal gray region. A subpopulation of inhibitory ZIm neurons expressing tachykinin 1 (TAC1) modulates the investigatory behavior.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Sustancia Gris Periacueductal
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Corteza Cerebral
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Corteza Prefrontal
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Conducta Exploratoria
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Zona Incerta
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Neuronas
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
2021
Tipo del documento:
Article