Construction of gem-Difluoroenol Esters through Catalytic O-Selective Addition of Difluoroenoxysilanes to Ketenes.
J Org Chem
; 86(11): 7797-7805, 2021 06 04.
Article
en En
| MEDLINE
| ID: mdl-34000179
ABSTRACT
The O-site reactivity of difluoroenoxysilanes is disclosed for the first time, which enabled the direct construction of versatile gem-difluoroalkenes through an unprecedented highly efficient addition reaction with ketenes. A series of valuable gem-difluoroenol esters were achieved in good to excellent yields. The synthetic versatility of this protocol is further demonstrated by the gram-scale synthesis and good functional group tolerance.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Ésteres
/
Cetonas
Idioma:
En
Revista:
J Org Chem
Año:
2021
Tipo del documento:
Article
País de afiliación:
China