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Contribution of lncRNA CASC8, CASC11, and PVT1 Genetic Variants to the Susceptibility of Coronary Heart Disease.
Lu, Yan; Yuan, Wei; Wang, Lan; Ning, Mingan; Han, Yuan; Gu, Wenjuan; Zhao, Tingting; Shang, Fenqing; Guo, Xuan.
Afiliación
  • Lu Y; Department of Cardiovasology, The First Hospital of Xi'an, Shaanxi, China.
  • Yuan W; Department of Cardiovasology, Xi'an Qinghua Hospital, Xi'an, China. ; and.
  • Wang L; Department of Cardiovasology, The First Hospital of Xi'an, Shaanxi, China.
  • Ning M; Department of Cardiovasology, The First Hospital of Xi'an, Shaanxi, China.
  • Han Y; Department of Cardiovasology, The First Hospital of Xi'an, Shaanxi, China.
  • Gu W; Department of Cardiovasology, The First Hospital of Xi'an, Shaanxi, China.
  • Zhao T; Department of Cardiovasology, The First Hospital of Xi'an, Shaanxi, China.
  • Shang F; Department of Cardiovasology, The First Hospital of Xi'an, Shaanxi, China.
  • Guo X; Department of Cardiovasology, The First Hospital of Xi'an, Shaanxi, China.
J Cardiovasc Pharmacol ; 77(6): 756-766, 2021 06 01.
Article en En | MEDLINE | ID: mdl-34001726
ABSTRACT: The purpose of this study was to explore the relationship between lncRNA CASC8, CASC11, and plasmacytoma variant translocation 1 (PVT1). genetic variants and coronary heart disease (CHD) susceptibility among a Chinese Han population. Five single nucleotide polymorphisms were genotyped by Agena MassARRAY platform among 464 CHD patients and 510 healthy controls. Binary logistic regression models by calculating odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association between selected single nucleotide polymorphisms and CHD risk. Multifactor dimensionality reduction analysis was performed to analyze gene-gene interaction. PVT1 rs4410871 (OR = 0.77, P = 0.040) was associated with a reduced risk of CHD occurrence in the Chinese population. CASC11 rs9642880 (OR = 1.49, P = 0.021) was a risk factor for increased CHD susceptibility in subjects over 60 years old, and PVT1 rs4410871 was a protective factor for CHD susceptibility in males (OR = 0.67, P = 0.015) and smokers (OR = 0.62, P = 0.047). Complications (hypertension or diabetes) of CHD influenced the association between CASC8, CASC11, and PVT1 genetic polymorphisms and CHD predisposition. Moreover, CASC8, CASC11, and PVT1 polymorphisms were related to the number of pathological branches and Gensini score in CHD patients. The study displayed the contribution of CASC8, CASC11, and PVT1 genetic polymorphisms to CHD predisposition, and these variants could serve as potential biomarkers of CHD susceptibility. These findings contribute to enhancing the understanding of the role of lncRNA polymorphisms in CHD risk.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedad Coronaria / ARN Largo no Codificante Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Cardiovasc Pharmacol Año: 2021 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedad Coronaria / ARN Largo no Codificante Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Cardiovasc Pharmacol Año: 2021 Tipo del documento: Article País de afiliación: China