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Treatment age and neurocognitive outcomes following proton beam radiotherapy for pediatric low- and intermediate-grade gliomas.
Heitzer, Andrew M; Kahalley, Lisa S; Minard, Charles G; Stafford, Claire; Grosshans, David R; Okcu, M Fatih; Raghubar, Kimberly P; Gragert, Marsha; McCurdy, Mark; Warren, Emily H; Gomez, Jocelyn; Ris, M Douglas; Paulino, Arnold C; Chintagumpala, Murali.
Afiliación
  • Heitzer AM; Psychology Department, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Kahalley LS; Department of Pediatrics, Section of Psychology, Baylor College of Medicine, Houston, Texas, USA.
  • Minard CG; Dan L. Duncan Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, Texas, USA.
  • Stafford C; Psychology Department, Macalester College, St. Paul, Minnesota, USA.
  • Grosshans DR; Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Okcu MF; Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas, USA.
  • Raghubar KP; Department of Pediatrics, Section of Psychology, Baylor College of Medicine, Houston, Texas, USA.
  • Gragert M; Department of Pediatrics, Section of Psychology, Baylor College of Medicine, Houston, Texas, USA.
  • McCurdy M; Department of Pediatrics, Section of Psychology, Baylor College of Medicine, Houston, Texas, USA.
  • Warren EH; Department of Pediatrics, Section of Psychology, Baylor College of Medicine, Houston, Texas, USA.
  • Gomez J; Department of Pediatrics, Section of Psychology, Baylor College of Medicine, Houston, Texas, USA.
  • Ris MD; Department of Pediatrics, Section of Psychology, Baylor College of Medicine, Houston, Texas, USA.
  • Paulino AC; Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Chintagumpala M; Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas, USA.
Pediatr Blood Cancer ; 68(8): e29096, 2021 08.
Article en En | MEDLINE | ID: mdl-34019329
ABSTRACT
The relationship between age and neurocognitive functioning following proton beam radiotherapy (PRT) in low- and intermediate-grade gliomas (LIGG) has yet to be examined. Eighteen LIGG patients treated with PRT were prospectively enrolled and received annual neurocognitive evaluations of perceptual/verbal reasoning, working memory, and processing speed postradiotherapy. The median age at diagnosis was 8.2 years (range 1.0-14.7) and the median age at PRT was 9.9 years (range 4.2-17.0). Patients' neurocognitive performance did not change on any measure following PRT (p ≥ .142). We did not observe significant changes in cognitive function over time among a small group of LIGG patients treated with PRT.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Cognición / Irradiación Craneoespinal / Terapia de Protones / Glioma Límite: Adolescent / Child / Child, preschool / Humans / Infant Idioma: En Revista: Pediatr Blood Cancer Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Cognición / Irradiación Craneoespinal / Terapia de Protones / Glioma Límite: Adolescent / Child / Child, preschool / Humans / Infant Idioma: En Revista: Pediatr Blood Cancer Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos