Overcoming the challenges of tissue delivery for oligonucleotide therapeutics.

Gökirmak, Tufan; Nikan, Mehran; Wiechmann, Svenja; Prakash, Thazha P; Tanowitz, Michael; Seth, Punit P

Gökirmak, Tufan; Nikan, Mehran; Wiechmann, Svenja; Prakash, Thazha P; Tanowitz, Michael; Seth, Punit P.

Afiliación

Gökirmak T; Department of Medicinal Chemistry, Ionis Pharmaceuticals, Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Nikan M; Department of Medicinal Chemistry, Ionis Pharmaceuticals, Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Wiechmann S; Department of Medicinal Chemistry, Ionis Pharmaceuticals, Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Prakash TP; Department of Medicinal Chemistry, Ionis Pharmaceuticals, Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Tanowitz M; Department of Medicinal Chemistry, Ionis Pharmaceuticals, Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Seth PP; Department of Medicinal Chemistry, Ionis Pharmaceuticals, Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA. Electronic address: PSeth@ionisph.com.

Trends Pharmacol Sci ; 42(7): 588-604, 2021 07.

Article en En | MEDLINE | ID: mdl-34020790

Asunto(s)

Oligonucleótidos Antisentido; Oligonucleótidos; Descubrimiento de Drogas; ARN Interferente Pequeño

Palabras clave

antisense oligonucleotides (ASO); endocytic uptake and escape; receptor-mediated drug delivery; siRNA; synthetic therapeutic oligonucleotides (STO); tissue distribution

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Oligonucleótidos / Oligonucleótidos Antisentido Idioma: En Revista: Trends Pharmacol Sci Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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