Embryonic macrophages function during early life to determine invariant natural killer T cell levels at barrier surfaces.
Nat Immunol
; 22(6): 699-710, 2021 06.
Article
en En
| MEDLINE
| ID: mdl-34040226
ABSTRACT
It is increasingly recognized that immune development within mucosal tissues is under the control of environmental factors during early life. However, the cellular mechanisms that underlie such temporally and regionally restrictive governance of these processes are unclear. Here, we uncover an extrathymic pathway of immune development within the colon that is controlled by embryonic but not bone marrow-derived macrophages, which determines the ability of these organs to receive invariant natural killer T (iNKT) cells and allow them to establish local residency. Consequently, early-life perturbations of fetal-derived macrophages result in persistent decreases of mucosal iNKT cells and is associated with later-life susceptibility or resistance to iNKT cell-associated mucosal disorders. These studies uncover a host developmental program orchestrated by ontogenically distinct macrophages that is regulated by microbiota, and they reveal an important postnatal function of macrophages that emerge in fetal life.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Colitis
/
Células T Invariantes Asociadas a Mucosa
/
Mucosa Intestinal
/
Listeriosis
/
Macrófagos
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Nat Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos