Features and mechanisms of canonical and noncanonical genomic imprinting.
Genes Dev
; 35(11-12): 821-834, 2021 06.
Article
en En
| MEDLINE
| ID: mdl-34074696
ABSTRACT
Genomic imprinting is the monoallelic expression of a gene based on parent of origin and is a consequence of differential epigenetic marking between the male and female germlines. Canonically, genomic imprinting is mediated by allelic DNA methylation. However, recently it has been shown that maternal H3K27me3 can result in DNA methylation-independent imprinting, termed "noncanonical imprinting." In this review, we compare and contrast what is currently known about the underlying mechanisms, the role of endogenous retroviral elements, and the conservation of canonical and noncanonical genomic imprinting.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Impresión Genómica
Límite:
Humans
Idioma:
En
Revista:
Genes Dev
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2021
Tipo del documento:
Article
País de afiliación:
Reino Unido