HIV-1 and human genetic variation.
Nat Rev Genet
; 22(10): 645-657, 2021 10.
Article
en En
| MEDLINE
| ID: mdl-34168330
ABSTRACT
Over the past four decades, research on the natural history of HIV infection has described how HIV wreaks havoc on human immunity and causes AIDS. HIV host genomic research, which aims to understand how human genetic variation affects our response to HIV infection, has progressed from early candidate gene studies to recent multi-omic efforts, benefiting from spectacular advances in sequencing technology and data science. In addition to invading cells and co-opting the host machinery for replication, HIV also stably integrates into our own genome. The study of the complex interactions between the human and retroviral genomes has improved our understanding of pathogenic mechanisms and suggested novel preventive and therapeutic approaches against HIV infection.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Variación Genética
/
Genoma Humano
/
Infecciones por VIH
/
VIH-1
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Interacciones Huésped-Patógeno
Límite:
Humans
Idioma:
En
Revista:
Nat Rev Genet
Asunto de la revista:
GENETICA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Canadá