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Sterilizing Effects of Novel Regimens Containing TB47, Clofazimine, and Linezolid in a Murine Model of Tuberculosis.
Yu, Wei; Yusuf, Buhari; Wang, Shuai; Tian, Xirong; Hameed, H M Adnan; Lu, Zhili; Chiwala, Gift; Alam, Md Shah; Cook, Gregory M; Maslov, Dmitry A; Zhong, Nanshan; Zhang, Tianyu.
Afiliación
  • Yu W; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
  • Yusuf B; Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
  • Wang S; University of Chinese Academy of Sciences, Beijing, China.
  • Tian X; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
  • Hameed HMA; Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
  • Lu Z; University of Chinese Academy of Sciences, Beijing, China.
  • Chiwala G; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
  • Alam MS; Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
  • Cook GM; University of Chinese Academy of Sciences, Beijing, China.
  • Maslov DA; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
  • Zhong N; Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
  • Zhang T; Institute of Physical Science and Information Technology, Anhui University, Hefei, China.
Antimicrob Agents Chemother ; 65(10): e0070621, 2021 09 17.
Article en En | MEDLINE | ID: mdl-34280022
ABSTRACT
TB47, a new drug candidate targeting QcrB in the electron transport chain, has shown a unique synergistic activity with clofazimine and forms a highly sterilizing combination. Here, we investigated the sterilizing effects of several all-oral regimens containing TB47 plus clofazimine and linezolid as a block and the roles of fluoroquinolones and pyrazinamide in them. All these regimens cured tuberculosis within 4 to 6 months in a well-established mouse model, and adding pyrazinamide showed a significant difference in bactericidal effects.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Tuberculosis / Mycobacterium tuberculosis Límite: Animals Idioma: En Revista: Antimicrob Agents Chemother Año: 2021 Tipo del documento: Article País de afiliación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Tuberculosis / Mycobacterium tuberculosis Límite: Animals Idioma: En Revista: Antimicrob Agents Chemother Año: 2021 Tipo del documento: Article País de afiliación: China