Acute and 28-days subacute toxicity studies of Gαq-RGS2 signaling inhibitor.
Lab Anim Res
; 37(1): 17, 2021 Jul 26.
Article
en En
| MEDLINE
| ID: mdl-34311782
ABSTRACT
BACKGROUND:
The aim of study was to evaluate the single oral dose and 28 day repeated oral administration toxicity profile of the synthetic compound Gαq-RGS2 signaling inhibitor, (1-(5-chloro-2-hydroxyphenyl)-3-(4-(trifluoromethyl)phenyl)-1 H-1,2,4-triazol-5(4 H)-one) as per OECD guideline 425 (2008a) and 407 (2008b), respectively.RESULTS:
In acute toxicity study, a single oral dose administration of Gαq-RGS2 signaling inhibitor did not show any mortality at doses of 5, 50, 300 and 2000 mg/kg within 24 h and 14 days. The treatment of Gαq-RGS2 signaling inhibitor at dose 10 and 100 mg/kg for 28 days did not show any mortality, significant changes in the increase of body weight, various organ damage markers, hematological parameters, relative organ/body weight ratio and microscopic anatomical texture of essential organs as compared to vehicle and normal control.CONCLUSIONS:
A single oral administration of Gαq-RGS2 signaling inhibitor up to dose of 2000 mg/kg in mice and repeated administration of Gαq-RGS2 signaling inhibitor at higher dose 100 mg/kg for 28 days in the rats is safe.
Texto completo:
1
Bases de datos:
MEDLINE
Tipo de estudio:
Guideline
Idioma:
En
Revista:
Lab Anim Res
Año:
2021
Tipo del documento:
Article
País de afiliación:
India