Your browser doesn't support javascript.
loading
Olfaction, cholinergic basal forebrain degeneration, and cognition in early Parkinson disease.
Barrett, Matthew J; Murphy, Justin M; Zhang, Jeffrey; Blair, Jamie C; Flanigan, Joseph L; Nawaz, Huma; Dalrymple, W Alex; Sperling, Scott A; Patrie, James; Druzgal, T Jason.
Afiliación
  • Barrett MJ; Department of Neurology, Virginia Commonwealth University, Richmond, VA, USA. Electronic address: matthew.barrett@vcuhealth.org.
  • Murphy JM; School of Medicine, University of Virginia, Charlottesville, VA, USA.
  • Zhang J; School of Medicine, University of Virginia, Charlottesville, VA, USA.
  • Blair JC; Department of Radiology and Medical Imaging, Division of Neuroradiology, University of Virginia Health System, Charlottesville, VA, USA.
  • Flanigan JL; Department of Neurology, University of Virginia, Charlottesville, VA, USA.
  • Nawaz H; Department of Neurology, Virginia Commonwealth University, Richmond, VA, USA.
  • Dalrymple WA; Department of Neurology, University of Virginia, Charlottesville, VA, USA.
  • Sperling SA; Department of Neurology, University of Virginia, Charlottesville, VA, USA.
  • Patrie J; Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
  • Druzgal TJ; Department of Radiology and Medical Imaging, Division of Neuroradiology, University of Virginia Health System, Charlottesville, VA, USA.
Parkinsonism Relat Disord ; 90: 27-32, 2021 09.
Article en En | MEDLINE | ID: mdl-34348192
INTRODUCTION: Impaired olfaction and reduced cholinergic nucleus 4 (Ch4) volume both predict greater cognitive decline in Parkinson's disease (PD). We examined the relationship between olfaction, longitudinal change in cholinergic basal forebrain nuclei and their target regions, and cognition in early PD. METHODS: We analyzed a cohort of 97 PD participants from the Parkinson's Progression Markers Initiative with brain MRIs at baseline, 1 year, 2 years, and 4 years. Using probabilistic maps, regional grey matter density (GMD) was calculated for Ch4, cholinergic nuclei 1, 2, and 3 (Ch123), and their target regions. RESULTS: Baseline University of Pennsylvania Smell Identification Test score correlated with change in GMD of all regions of interest (all p < 0.05). Rate of change of Ch4 GMD was correlated with rate of change of Ch123 (p = 0.034), cortex (p = 0.001), and amygdala GMD (p < 0.001), but not hippocampus GMD (p = 0.38). Rate of change of Ch123 GMD was correlated with rate of change of cortex (p = 0.001) and hippocampus (p < 0.001), but not amygdala GMD (p = 0.133). In a linear regression model including change in GMD of all regions of interest and age as predictors, change in cortex GMD (߈slope= 38.2; 95 % CI: [0.47, 75.9]) and change in hippocampus GMD (߈slope= 24.8; 95 % CI: [0.80, 48.8]) were significant predictors of Montreal Cognitive Assessment score change over time. CONCLUSION: Impaired olfaction is associated with degeneration of the cholinergic basal forebrain and bilateral cortex, amygdala, and hippocampus in PD. The relationship between impaired olfaction and cognitive decline may be mediated by greater atrophy of the cortex and hippocampus.
Asunto(s)
Palabras clave

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Olfato / Cognición / Prosencéfalo Basal Tipo de estudio: Observational_studies / Prognostic_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: Parkinsonism Relat Disord Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Olfato / Cognición / Prosencéfalo Basal Tipo de estudio: Observational_studies / Prognostic_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: Parkinsonism Relat Disord Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article