Improved Specificity and Safety of Anti-Hepatitis B Virus TALENs Using Obligate Heterodimeric <i>Fok</i>I Nuclease Domains.

Smith, Tiffany; Singh, Prashika; Chmielewski, Kay Ole; Bloom, Kristie; Cathomen, Toni; Arbuthnot, Patrick; Ely, Abdullah

Improved Specificity and Safety of Anti-Hepatitis B Virus TALENs Using Obligate Heterodimeric FokI Nuclease Domains.

Smith, Tiffany; Singh, Prashika; Chmielewski, Kay Ole; Bloom, Kristie; Cathomen, Toni; Arbuthnot, Patrick; Ely, Abdullah.

Afiliación

Smith T; Wits/SAMRC Antiviral Gene Therapy Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown 2193, South Africa.
Singh P; Wits/SAMRC Antiviral Gene Therapy Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown 2193, South Africa.
Chmielewski KO; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg & Medical Faculty, University of Freiburg, 79106 Freiburg, Germany.
Bloom K; Wits/SAMRC Antiviral Gene Therapy Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown 2193, South Africa.
Cathomen T; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg & Medical Faculty, University of Freiburg, 79106 Freiburg, Germany.
Arbuthnot P; Wits/SAMRC Antiviral Gene Therapy Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown 2193, South Africa.
Ely A; Wits/SAMRC Antiviral Gene Therapy Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown 2193, South Africa.

Viruses ; 13(7)2021 07 12.

Article en En | MEDLINE | ID: mdl-34372550

Asunto(s)

Virus de la Hepatitis B/genética; Hepatitis B/tratamiento farmacológico; Nucleasas de los Efectores Tipo Activadores de la Transcripción/genética; Animales; Animales no Consanguíneos; Antivirales/uso terapéutico; Línea Celular; Virus ADN/genética; ADN Circular; ADN Viral/genética; Desoxirribonucleasas de Localización Especificada Tipo II/genética; Desoxirribonucleasas de Localización Especificada Tipo II/metabolismo; Modelos Animales de Enfermedad; Endonucleasas/genética; Femenino; Terapia Genética/métodos; Células HEK293; Células Hep G2; Hepatitis B/genética; Hepatitis B/inmunología; Hepatitis B Crónica/genética; Hepatitis B Crónica/virología; Humanos; Ratones; Nucleasas de los Efectores Tipo Activadores de la Transcripción/uso terapéutico; Replicación Viral/genética

Palabras clave

HBV; Sharkey; cccDNA; obligate heterodimeric TALENs

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Virus de la Hepatitis B / Nucleasas de los Efectores Tipo Activadores de la Transcripción / Hepatitis B Límite: Animals / Female / Humans Idioma: En Revista: Viruses Año: 2021 Tipo del documento: Article País de afiliación: Sudáfrica

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