Development of fluorinated and methoxylated benzothiazole derivatives as highly potent and selective cannabinoid CB<sub>2</sub> receptor ligands.

Aly, Mayar W; Ludwig, Friedrich-Alexander; Deuther-Conrad, Winnie; Brust, Peter; Abadi, Ashraf H; Moldovan, Rares-Petru; Osman, Noha A

Development of fluorinated and methoxylated benzothiazole derivatives as highly potent and selective cannabinoid CB₂ receptor ligands.

Aly, Mayar W; Ludwig, Friedrich-Alexander; Deuther-Conrad, Winnie; Brust, Peter; Abadi, Ashraf H; Moldovan, Rares-Petru; Osman, Noha A.

Afiliación

Aly MW; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Egypt.
Ludwig FA; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals, Research Site Leipzig, Leipzig 04318, Germany.
Deuther-Conrad W; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals, Research Site Leipzig, Leipzig 04318, Germany.
Brust P; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals, Research Site Leipzig, Leipzig 04318, Germany.
Abadi AH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Egypt.
Moldovan RP; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals, Research Site Leipzig, Leipzig 04318, Germany. Electronic address: r.moldovan@hzdr.de.
Osman NA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Egypt. Electronic address: nohaabdelazizosman@gmail.com.

Bioorg Chem ; 114: 105191, 2021 09.

Article en En | MEDLINE | ID: mdl-34375194

Asunto(s)

Benzotiazoles/farmacología; Desarrollo de Medicamentos; Receptor Cannabinoide CB2/metabolismo; Animales; Benzotiazoles/síntesis química; Benzotiazoles/química; Relación Dosis-Respuesta a Droga; Halogenación; Humanos; Ligandos; Ratones; Microsomas Hepáticos/química; Microsomas Hepáticos/metabolismo; Estructura Molecular; Relación Estructura-Actividad

Palabras clave

Benzothiazole; CB(2) ligands; Cannabinoid receptor type 2; Fluorine; Metabolic studies; PET

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Receptor Cannabinoide CB2 / Benzotiazoles / Desarrollo de Medicamentos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Bioorg Chem Año: 2021 Tipo del documento: Article País de afiliación: Egipto

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