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Prognostic Significance of Microvascular Invasion in Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-Analysis.
Li, Huangbao; Pan, Weiwei; Xu, Liu; Yin, Dong; Cheng, Shuqun; Zhao, Fengqing.
Afiliación
  • Li H; Department of Hepatobiliary and Pancreatic Surgery, First Hospital of Jiaxing, First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China (mainland).
  • Pan W; Department of Cell Biology, College of Medicine, Jiaxing University, Jiaxing, Zhejiang, China (mainland).
  • Xu L; Department of Hepatobiliary and Pancreatic Surgery, First Hospital of Jiaxing, First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China (mainland).
  • Yin D; Department of Oncology, First Hospital of Jiaxing, First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China (mainland).
  • Cheng S; Department of Oncology, First Hospital of Jiaxing, First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China (mainland).
  • Zhao F; Department of Hepatic Surgery IV, The Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China (mainland).
Med Sci Monit ; 27: e930545, 2021 Aug 16.
Article en En | MEDLINE | ID: mdl-34393219
ABSTRACT
BACKGROUND The incidence, pathogenesis, and prognostic effect of microvascular invasion on pancreatic ductal adenocarcinoma (PDAC) remain controversial. This study aimed to summarize the incidence, pathogenesis, role in clinical management, recurrence, and prognostic significance of microvascular invasion in PDAC. MATERIAL AND METHODS A literature review and meta-analysis were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Systematic literature searches were conducted using PubMed and Google Scholar up to February 2021. RESULTS Seventeen studies were included in the meta-analysis. The incidence of microvascular invasion was 49.0% (95% confidence interval [CI], 43.8-54.5%) among PDAC patients who underwent surgery. The weighted multivariate Cox proportional hazards model hazard ratio for disease-free survival of 8 studies was 1.78 (95% CI 1.53-2.08, P<0.001), and there was no statistically significant difference between the subgroups (P=0.477). The hazard ratio for overall survival of 14 studies was 1.49 (95% CI 1.27-1.74, P<0.001), and there was no statistically significant difference between the subgroups (P=0.676). CONCLUSIONS Microvascular invasion occurred in nearly half of PDAC patients after surgery and was closely related to disease-free and overall survival. Understanding the role of microvascular invasion in PDAC will help provide more personalized and effective preoperative or postoperative strategies to achieve better survival outcomes.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Carcinoma Ductal Pancreático / Invasividad Neoplásica Tipo de estudio: Incidence_studies / Prognostic_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Med Sci Monit Asunto de la revista: MEDICINA Año: 2021 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Carcinoma Ductal Pancreático / Invasividad Neoplásica Tipo de estudio: Incidence_studies / Prognostic_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Med Sci Monit Asunto de la revista: MEDICINA Año: 2021 Tipo del documento: Article