Refractory acquired thrombotic thrombocytopenic purpura in a patient with sickle cell trait successfully treated with caplacizumab.
Hematology
; 26(1): 590-593, 2021 Dec.
Article
en En
| MEDLINE
| ID: mdl-34396933
ABSTRACT
Methods:
We report a case of a 20-year-old Nigerian male who presented with acquired thrombotic thrombocytopenic purpura (aTTP) and sickle cell trait. The coexistence of published cases of TTP and sickle cell hemoglobinopathies is rare.Results:
Despite the initial treatment with plasma exchange and glucocorticoids, our patient relapsed and also required caplacizumab which resulted in successful remission.Discussion:
We conclude by reviewing the cases of TTP in patients with sickle cell hemoglobinopathies and review how vaso-occlusive crises with multiorgan injury can mimic TTP.Conclusion:
Ours is the first published case of aTTP with confirmed ADAMTS13 autoantibodies in a patient with a sickle cell hemoglobinopathy and contributes to the literature on the successful use of caplacizumab in clinical practice.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Púrpura Trombocitopénica Trombótica
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Rasgo Drepanocítico
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Fibrinolíticos
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Anticuerpos de Dominio Único
Límite:
Adult
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Humans
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Male
Idioma:
En
Revista:
Hematology
Asunto de la revista:
HEMATOLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Canadá