Metabolic engineering of microorganisms for L-alanine production.
J Ind Microbiol Biotechnol
; 49(2)2022 Apr 14.
Article
en En
| MEDLINE
| ID: mdl-34410417
ABSTRACT
L-alanine is extensively used in chemical, food, and medicine industries. Industrial production of L-alanine has been mainly based on the enzymatic process using petroleum-based L-aspartic acid as the substrate. L-alanine production from renewable biomass using microbial fermentation process is an alternative route. Many microorganisms can naturally produce L-alanine using aminotransferase or L-alanine dehydrogenase. However, production of L-alanine using the native strains has been limited due to their low yields and productivities. In this review, metabolic engineering of microorganisms for L-alanine production was summarized. Among them, the Escherichia coli strains developed by Dr. Lonnie Ingram's group which can produce L-alanine with anaerobic fermentation process had several advantages, especially having high L-alanine yield, and it was the first one that realized commercialization. L-alanine is also the first amino acid that could be industrially produced by anaerobic fermentation.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Escherichia coli
/
Ingeniería Metabólica
Idioma:
En
Revista:
J Ind Microbiol Biotechnol
Asunto de la revista:
BIOTECNOLOGIA
/
MICROBIOLOGIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
China