Evaluation of Gibbilimbol B, Isolated from Piper malacophyllum (Piperaceae), as an Antischistosomal Agent.
Chem Biodivers
; 18(10): e2100503, 2021 Oct.
Article
en En
| MEDLINE
| ID: mdl-34418297
ABSTRACT
Infections caused by parasitic worms impose a considerable worldwide health burden. One of the most impactful is schistosomiasis, a disease caused by blood-dwelling of the genus Schistosoma that affects more than 230â
million people worldwide. Since praziquantel has also been extensively used to treat schistosomiasis and other parasitic flatworm infections, there is an urgent need to identify novel anthelmintic compounds, mainly from natural sources. In this study, the hexane extract from roots of Piper malacophyllum (Piperaceae) showed to be mainly composed for gibbilimbolâ
B by HPLC/ESI-HRMS. Based on this result, this compound was isolated by chromatographic steps and its structure was confirmed by NMR. Inâ
vitro bioassays showed that gibbilimbolâ
B was more active than praziquantel against larval stage of S.â
mansoni, with effective concentrations of 50 % (EC50 ) and 90 % (EC90 ) values of 2.6 and 3.4â
µM, respectively. Importantly, gibbilimbolâ
B showed no cytotoxicity to mammalian cells at a concentration 190â
times greater than the antiparasitic effect, giving support for the anthelmintic potential of gibbilimbolâ
B as lead compound for novel antischistosomal agents.
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Texto completo:
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Bases de datos:
MEDLINE
Asunto principal:
Fenoles
/
Schistosoma mansoni
/
Extractos Vegetales
/
Piperaceae
Límite:
Animals
Idioma:
En
Revista:
Chem Biodivers
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Brasil