Synthesis and biological evaluation of 1,6-bis-triazole-2,3,4-tri-O-benzyl-&#945;-d-glucopyranosides as a novel &#945;-glucosidase inhibitor in the treatment of Type 2 diabetes.

Chaidam, Suksamran; Saehlim, Natthiya; Athipornchai, Anan; Sirion, Uthaiwan; Saeeng, Rungnapha

Synthesis and biological evaluation of 1,6-bis-triazole-2,3,4-tri-O-benzyl-α-d-glucopyranosides as a novel α-glucosidase inhibitor in the treatment of Type 2 diabetes.

Chaidam, Suksamran; Saehlim, Natthiya; Athipornchai, Anan; Sirion, Uthaiwan; Saeeng, Rungnapha.

Afiliación

Chaidam S; Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Burapha University, Sangesook, ChonBuri 20131, Thailand.
Saehlim N; Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Burapha University, Sangesook, ChonBuri 20131, Thailand.
Athipornchai A; Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Burapha University, Sangesook, ChonBuri 20131, Thailand; The Research Unit in Synthetic Compounds and Synthetic Analogues from Natural Product for Drug Discovery (RSND), Burapha University, Chonburi 201
Sirion U; Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Burapha University, Sangesook, ChonBuri 20131, Thailand; The Research Unit in Synthetic Compounds and Synthetic Analogues from Natural Product for Drug Discovery (RSND), Burapha University, Chonburi 201
Saeeng R; Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Burapha University, Sangesook, ChonBuri 20131, Thailand; The Research Unit in Synthetic Compounds and Synthetic Analogues from Natural Product for Drug Discovery (RSND), Burapha University, Chonburi 201

Bioorg Med Chem Lett ; 50: 128331, 2021 10 15.

Article en En | MEDLINE | ID: mdl-34418573

Asunto(s)

Diabetes Mellitus Tipo 2/tratamiento farmacológico; Glucanos/farmacología; Inhibidores de Glicósido Hidrolasas/farmacología; Hipoglucemiantes/síntesis química; Hipoglucemiantes/farmacología; Humanos; Modelos Moleculares; Simulación del Acoplamiento Molecular; Estructura Molecular; Unión Proteica; Conformación Proteica; alfa-Glucosidasas/química; alfa-Glucosidasas/metabolismo

Palabras clave

Bis-triazole glucoside; Sugar; Type 2 diabetes mellitus; α-glucosidase inhibitor

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Inhibidores de Glicósido Hidrolasas / Glucanos / Hipoglucemiantes Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Tailandia

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