The Natural Product ß-Escin Targets Cancer and Stromal Cells of the Tumor Microenvironment to Inhibit Ovarian Cancer Metastasis.

Kenny, Hilary A; Hart, Peter C; Kordylewicz, Kasjusz; Lal, Madhu; Shen, Min; Kara, Betul; Chen, Yen-Ju; Grassl, Niklas; Alharbi, Yousef; Pattnaik, Bikash R; Watters, Karen M; Patankar, Manish S; Ferrer, Marc; Lengyel, Ernst

Kenny, Hilary A; Hart, Peter C; Kordylewicz, Kasjusz; Lal, Madhu; Shen, Min; Kara, Betul; Chen, Yen-Ju; Grassl, Niklas; Alharbi, Yousef; Pattnaik, Bikash R; Watters, Karen M; Patankar, Manish S; Ferrer, Marc; Lengyel, Ernst.

Afiliación

Kenny HA; Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA.
Hart PC; Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA.
Kordylewicz K; Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA.
Lal M; Division of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), NIH, Rockville, MD 20852, USA.
Shen M; Division of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), NIH, Rockville, MD 20852, USA.
Kara B; Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA.
Chen YJ; Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA.
Grassl N; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
Alharbi Y; Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI 53792, USA.
Pattnaik BR; Department of Pediatrics and Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Watters KM; Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA.
Patankar MS; Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI 53792, USA.
Ferrer M; Division of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), NIH, Rockville, MD 20852, USA.
Lengyel E; Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA.

Cancers (Basel) ; 13(16)2021 Aug 04.

Article en En | MEDLINE | ID: mdl-34439084

Palabras clave

Digitoxin; Ouabain; high-throughput screening; metastasis; ovarian cancer; tumor microenvironment; ß-escin

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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos