Diagnosing coeliac disease: A literature review.
Hum Immunol
; 82(12): 930-936, 2021 Dec.
Article
en En
| MEDLINE
| ID: mdl-34462157
ABSTRACT
Coeliac disease (CD) is an autoimmune gastroenteropathy triggered by gliadin and gliadin-tissue transglutaminase (tTG) complexes. CD is one of the few autoimmune diseases with an accurate, non-invasive serological test. Anti-endomysial, anti-tTG and anti-deaminated gliadin peptides (DGP) antibodies are currently used for serological tests with tTG ELISAs being the superior test. Duodenal biopsy, although invasive, is the gold standard for CD diagnosis. HLA genotyping and flow cytometry can also be used as supplementary tests. The incidence of CD is rising globally although the reasons for this remain unclear. In addition, the true incidence of coeliac disease in African populations remains unknown although recent work suggests that South African populations express the alleles associated with this disease. This review examines the pathogenesis and diagnosis of coeliac disease and considers novel and innovative biomarkers in its diagnosis specifically in an African population.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Enfermedad Celíaca
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Duodeno
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Proteína Glutamina Gamma Glutamiltransferasa 2
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Gliadina
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Antígenos HLA
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Anticuerpos
Tipo de estudio:
Diagnostic_studies
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Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Hum Immunol
Año:
2021
Tipo del documento:
Article