Protein Targets of Acetaminophen Covalent Binding in Rat and Mouse Liver Studied by LC-MS/MS.

Geib, Timon; Moghaddam, Ghazaleh; Supinski, Aimee; Golizeh, Makan; Sleno, Lekha

Geib, Timon; Moghaddam, Ghazaleh; Supinski, Aimee; Golizeh, Makan; Sleno, Lekha.

Afiliación

Geib T; Chemistry Department, Université du Québec à Montréal, Montréal, QC, Canada.
Moghaddam G; Chemistry Department, Université du Québec à Montréal, Montréal, QC, Canada.
Supinski A; Chemistry Department, Université du Québec à Montréal, Montréal, QC, Canada.
Golizeh M; Chemistry Department, Université du Québec à Montréal, Montréal, QC, Canada.
Sleno L; Chemistry Department, Université du Québec à Montréal, Montréal, QC, Canada.

Front Chem ; 9: 736788, 2021.

Article en En | MEDLINE | ID: mdl-34490218

Palabras clave

LC-MS/MS, LC-MRM; NAPQI, N-acetyl-p-benzoquinone; acetaminophen; covalent binding; mouse, rat; protein modification; reactive metabolites, liver proteins; rodent model

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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: Front Chem Año: 2021 Tipo del documento: Article País de afiliación: Canadá