Your browser doesn't support javascript.
loading
A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease.
Wightman, Douglas P; Jansen, Iris E; Savage, Jeanne E; Shadrin, Alexey A; Bahrami, Shahram; Holland, Dominic; Rongve, Arvid; Børte, Sigrid; Winsvold, Bendik S; Drange, Ole Kristian; Martinsen, Amy E; Skogholt, Anne Heidi; Willer, Cristen; Bråthen, Geir; Bosnes, Ingunn; Nielsen, Jonas Bille; Fritsche, Lars G; Thomas, Laurent F; Pedersen, Linda M; Gabrielsen, Maiken E; Johnsen, Marianne Bakke; Meisingset, Tore Wergeland; Zhou, Wei; Proitsi, Petroula; Hodges, Angela; Dobson, Richard; Velayudhan, Latha; Heilbron, Karl; Auton, Adam; Sealock, Julia M; Davis, Lea K; Pedersen, Nancy L; Reynolds, Chandra A; Karlsson, Ida K; Magnusson, Sigurdur; Stefansson, Hreinn; Thordardottir, Steinunn; Jonsson, Palmi V; Snaedal, Jon; Zettergren, Anna; Skoog, Ingmar; Kern, Silke; Waern, Margda; Zetterberg, Henrik; Blennow, Kaj; Stordal, Eystein; Hveem, Kristian; Zwart, John-Anker; Athanasiu, Lavinia; Selnes, Per.
Afiliación
  • Wightman DP; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, the Netherlands.
  • Jansen IE; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, the Netherlands.
  • Savage JE; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, the Netherlands.
  • Shadrin AA; NORMENT Centre, University of Oslo, Oslo, Norway.
  • Bahrami S; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Holland D; NORMENT Centre, University of Oslo, Oslo, Norway.
  • Rongve A; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Børte S; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
  • Winsvold BS; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
  • Drange OK; Department of Research and Innovation, Helse Fonna, Haugesund Hospital, Haugesund, Norway.
  • Martinsen AE; The University of Bergen, Institute of Clinical Medicine (K1), Bergen, Norway.
  • Skogholt AH; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Willer C; Research and Communication Unit for Musculoskeletal Health (FORMI), Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.
  • Bråthen G; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
  • Bosnes I; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
  • Nielsen JB; Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.
  • Fritsche LG; Department of Neurology, Oslo University Hospital, Oslo, Norway.
  • Thomas LF; Department of Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
  • Pedersen LM; Division of Mental Health Care, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
  • Gabrielsen ME; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Johnsen MB; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
  • Meisingset TW; Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.
  • Zhou W; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
  • Proitsi P; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
  • Hodges A; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
  • Dobson R; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
  • Velayudhan L; Department of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway.
  • Heilbron K; Department of Geriatrics, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.
  • Auton A; Department of Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
  • Sealock JM; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
  • Davis LK; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
  • Pedersen NL; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
  • Reynolds CA; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
  • Karlsson IK; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
  • Magnusson S; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
  • Stefansson H; Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.
  • Thordardottir S; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
  • Jonsson PV; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Snaedal J; Research and Communication Unit for Musculoskeletal Health (FORMI), Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.
  • Zettergren A; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
  • Skoog I; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
  • Kern S; Department of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway.
  • Waern M; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
  • Zetterberg H; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
  • Blennow K; Institute of Psychiatry Psychology and Neurosciences, King's College London, London, UK.
  • Stordal E; Institute of Psychiatry Psychology and Neurosciences, King's College London, London, UK.
  • Hveem K; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.
  • Zwart JA; NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, UK.
  • Athanasiu L; Health Data Research UK London, University College London, London, UK.
  • Selnes P; Institute of Health Informatics, University College London, London, UK.
Nat Genet ; 53(9): 1276-1282, 2021 09.
Article en En | MEDLINE | ID: mdl-34493870
ABSTRACT
Late-onset Alzheimer's disease is a prevalent age-related polygenic disease that accounts for 50-70% of dementia cases. Currently, only a fraction of the genetic variants underlying Alzheimer's disease have been identified. Here we show that increased sample sizes allowed identification of seven previously unidentified genetic loci contributing to Alzheimer's disease. This study highlights microglia, immune cells and protein catabolism as relevant to late-onset Alzheimer's disease, while identifying and prioritizing previously unidentified genes of potential interest. We anticipate that these results can be included in larger meta-analyses of Alzheimer's disease to identify further genetic variants that contribute to Alzheimer's pathology.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Predisposición Genética a la Enfermedad / Estudio de Asociación del Genoma Completo / Enfermedad de Alzheimer Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Predisposición Genética a la Enfermedad / Estudio de Asociación del Genoma Completo / Enfermedad de Alzheimer Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos