Synthesis of Aporphine Analogues via Palladium-Catalyzed Intramolecular Aryl-Aryl Dehydrogenative Coupling.

Su, Chen; Xu, Wen-Hua; Guo, Rui-Li; Zhang, Xing-Long; Zhu, Xue-Qing; Gao, Ya-Ru; Wang, Yong-Qiang

Su, Chen; Xu, Wen-Hua; Guo, Rui-Li; Zhang, Xing-Long; Zhu, Xue-Qing; Gao, Ya-Ru; Wang, Yong-Qiang.

Afiliación

Su C; Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an 710069, People's Republic of China.
Xu WH; Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an 710069, People's Republic of China.
Guo RL; Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an 710069, People's Republic of China.
Zhang XL; Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an 710069, People's Republic of China.
Zhu XQ; Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an 710069, People's Republic of China.
Gao YR; Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an 710069, People's Republic of China.
Wang YQ; Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an 710069, People's Republic of China.

J Org Chem ; 86(19): 13618-13630, 2021 10 01.

Article en En | MEDLINE | ID: mdl-34498883

ABSTRACT

ABSTRACT

Reported herein is an intramolecular dehydrogenative coupling of two inert aryl C-H bonds for the synthesis of aporphine analogues. The process represents a novel tool for the preparation of aporphines via palladiun-catalyzed C-H bond activation. The present reaction is compatible with various functional groups, and the coupling products have been further applied for the synthesis of natural products aporphine and zenkerine.

Asunto(s)

Aporfinas; Paladio; Catálisis

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Paladio / Aporfinas Idioma: En Revista: J Org Chem Año: 2021 Tipo del documento: Article