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REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps.
Taglialatela, Angelo; Leuzzi, Giuseppe; Sannino, Vincenzo; Cuella-Martin, Raquel; Huang, Jen-Wei; Wu-Baer, Foon; Baer, Richard; Costanzo, Vincenzo; Ciccia, Alberto.
Afiliación
  • Taglialatela A; Department of Genetics and Development, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.
  • Leuzzi G; Department of Genetics and Development, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.
  • Sannino V; DNA Metabolism Laboratory, IFOM, FIRC Institute for Molecular Oncology, Milan, Italy; Department of Oncology and Hematology-Oncology, University of Milan, Milan, Italy.
  • Cuella-Martin R; Department of Genetics and Development, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.
  • Huang JW; Department of Genetics and Development, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.
  • Wu-Baer F; Institute for Cancer Genetics, Department of Pathology & Cell Biology, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.
  • Baer R; Institute for Cancer Genetics, Department of Pathology & Cell Biology, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.
  • Costanzo V; DNA Metabolism Laboratory, IFOM, FIRC Institute for Molecular Oncology, Milan, Italy; Department of Oncology and Hematology-Oncology, University of Milan, Milan, Italy.
  • Ciccia A; Department of Genetics and Development, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA. Electronic address: ac3685@cumc.columbia.edu.
Mol Cell ; 81(19): 4008-4025.e7, 2021 10 07.
Article en En | MEDLINE | ID: mdl-34508659

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: ADN de Neoplasias / ADN Primasa / Proteínas de Unión al ADN / ADN Polimerasa Dirigida por ADN / Replicación del ADN / Roturas del ADN de Cadena Simple / Reparación del ADN por Recombinación / Enzimas Multifuncionales / Neoplasias / Nucleotidiltransferasas Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: ADN de Neoplasias / ADN Primasa / Proteínas de Unión al ADN / ADN Polimerasa Dirigida por ADN / Replicación del ADN / Roturas del ADN de Cadena Simple / Reparación del ADN por Recombinación / Enzimas Multifuncionales / Neoplasias / Nucleotidiltransferasas Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos