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A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics.
Al-Hamashi, Ayad A; Koranne, Radhika; Dlamini, Samkeliso; Alqahtani, Abdulateef; Karaj, Endri; Rashid, Maisha S; Knoff, Joseph R; Dunworth, Matthew; Pflum, Mary Kay H; Casero, Robert A; Perera, Lalith; Taylor, William R; Tillekeratne, L M Viranga.
Afiliación
  • Al-Hamashi AA; Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, 2801, W. Bancroft Street, Toledo, OH-43606, USA.
  • Koranne R; Department of Biological Sciences, College of Natural Sciences and Mathematics, The University of Toledo, 2801, W. Bancroft Street, Toledo, OH-43606, USA.
  • Dlamini S; Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, 2801, W. Bancroft Street, Toledo, OH-43606, USA.
  • Alqahtani A; Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, 2801, W. Bancroft Street, Toledo, OH-43606, USA.
  • Karaj E; Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, 2801, W. Bancroft Street, Toledo, OH-43606, USA.
  • Rashid MS; Department of Biological Sciences, College of Natural Sciences and Mathematics, The University of Toledo, 2801, W. Bancroft Street, Toledo, OH-43606, USA.
  • Knoff JR; Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, USA.
  • Dunworth M; The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Bunting/Blaustein Cancer Research Building 1 1650 Orleans Street - Room 551, Baltimore, MD 21231, USA.
  • Pflum MKH; Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, USA.
  • Casero RA; The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Bunting/Blaustein Cancer Research Building 1 1650 Orleans Street - Room 551, Baltimore, MD 21231, USA.
  • Perera L; Laboratory of Genome Integrity and Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
  • Taylor WR; Department of Biological Sciences, College of Natural Sciences and Mathematics, The University of Toledo, 2801, W. Bancroft Street, Toledo, OH-43606, USA. Electronic address: william.tayor2@utoledo.edu.
  • Tillekeratne LMV; Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, 2801, W. Bancroft Street, Toledo, OH-43606, USA. Electronic address: ltillek@utnet.utoledo.edu.
Bioorg Chem ; 116: 105297, 2021 11.
Article en En | MEDLINE | ID: mdl-34509798
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Citotoxinas / Etanol / Moduladores de Tubulina / Imidazoles / Microtúbulos / Antineoplásicos Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Citotoxinas / Etanol / Moduladores de Tubulina / Imidazoles / Microtúbulos / Antineoplásicos Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos