CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection.

Lu, Yu-Jung; Barreira-Silva, Palmira; Boyce, Shayla; Powers, Jennifer; Cavallo, Kelly; Behar, Samuel M

CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection.

Lu, Yu-Jung; Barreira-Silva, Palmira; Boyce, Shayla; Powers, Jennifer; Cavallo, Kelly; Behar, Samuel M.

Afiliación

Lu YJ; Immunology and Microbiology Program, Graduate School of Biomedical Science, University of Massachusetts Medical School, Worcester, MA, USA; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA.
Barreira-Silva P; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal; ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal.
Boyce S; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA.
Powers J; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA.
Cavallo K; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA.
Behar SM; Immunology and Microbiology Program, Graduate School of Biomedical Science, University of Massachusetts Medical School, Worcester, MA, USA; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA. Electronic address: samuel.behar@umassmed.

Cell Rep ; 36(11): 109696, 2021 09 14.

Article en En | MEDLINE | ID: mdl-34525366

Asunto(s)

Linfocitos T CD8-positivos/inmunología; Linfocitos T Colaboradores-Inductores/inmunología; Tuberculosis/inmunología; Animales; Linfocitos T CD8-positivos/citología; Linfocitos T CD8-positivos/metabolismo; Modelos Animales de Enfermedad; Antígenos de Histocompatibilidad Clase II/genética; Antígenos de Histocompatibilidad Clase II/metabolismo; Interferón gamma/metabolismo; Interleucina-2/metabolismo; Pulmón/microbiología; Pulmón/patología; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados; Mycobacterium tuberculosis/patogenicidad; Mycobacterium tuberculosis/fisiología; Subfamilia K de Receptores Similares a Lectina de Células NK/genética; Subfamilia K de Receptores Similares a Lectina de Células NK/metabolismo; Familia de Moléculas Señalizadoras de la Activación Linfocitaria/genética; Familia de Moléculas Señalizadoras de la Activación Linfocitaria/metabolismo; Tasa de Supervivencia; Linfocitos T Colaboradores-Inductores/citología; Linfocitos T Colaboradores-Inductores/metabolismo; Transcriptoma; Tuberculosis/mortalidad; Tuberculosis/patología

Palabras clave

CD4 T cell help; CD4 T cells; CD8 T cells; CTL; T cell exhaustion; immunity; infection; interferon gamma; lung; mycobacterium tuberculosis

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Tuberculosis / Linfocitos T Colaboradores-Inductores / Linfocitos T CD8-positivos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Cell Rep Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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